{"id":"W4403246432","doi":"10.1161/res.135.suppl_1.mo020","title":"Abstract Mo020: Loss of TRAF2 Signaling Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy","year":2024,"lang":"en","type":"article","venue":"Circulation Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Cardiomyopathy; TRAF2; Cancer research; Doxorubicin; Cardiac dysfunction; Medicine; Mitochondrion; Cell biology; Signal transduction; Biology; Chemistry; Heart failure; Internal medicine; Tumor necrosis factor alpha; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009911151,0.0001175092,0.0001688118,0.000399652,0.00006233202,0.00004835514,0.0001351655,0.0002718109,0.0002776836],"category_scores_gemma":[0.0005143614,0.000116269,0.0001204208,0.0005120622,0.0001288049,0.00001255566,0.00004827066,0.0003153545,0.00008137092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003978834,"about_ca_system_score_gemma":0.0001801338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009532172,"about_ca_topic_score_gemma":0.00006592299,"domain_scores_codex":[0.9982337,0.0002495454,0.000366579,0.0004639871,0.0003924785,0.0002937046],"domain_scores_gemma":[0.9992376,0.0001333547,0.00006801674,0.0002756981,0.0002105685,0.00007479086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001779416,0.00003849687,0.008489486,0.0001027427,0.0000265781,0.00002564033,0.0001512888,0.003730586,0.9838607,0.0002665543,0.001079986,0.002049985],"study_design_scores_gemma":[0.003787778,0.000829818,0.1396686,0.0003972688,0.00005177265,0.000109416,0.0008352662,0.007385472,0.8102543,0.003561555,0.03229737,0.0008214387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992463,0.001299203,0.002692563,0.0001764698,0.001363831,0.0003402555,0.00001628929,0.00002203471,0.001626349],"genre_scores_gemma":[0.9980452,0.0001235528,0.0001271911,0.00001934689,0.001207734,0.00004204061,0.0001919379,0.0000236566,0.000219358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1736065,"threshold_uncertainty_score":0.474131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04245012843259679,"score_gpt":0.3343811877725741,"score_spread":0.2919310593399774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}