{"id":"W4403249628","doi":"10.1038/s41398-024-03139-9","title":"Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder","year":2024,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Plan Nacional sobre Drogas; Ministerio de Sanidad, Servicios Sociales e Igualdad; Institució Catalana de Recerca i Estudis Avançats; Agència de Gestió d'Ajuts Universitaris i de Recerca; Fundació la Marató de TV3; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Ministerio de Ciencia, Innovación y Universidades","keywords":"DNA methylation; Gene expression profiling; Omics; Gene; Computational biology; Human genome; Gene expression; Profiling (computer programming); Methylation; Biology; Bioinformatics; Genetics; Medicine; Genome; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001657258,0.00009807517,0.00008728347,0.00009952226,0.00005535405,0.00002745002,0.00003929836,0.000107533,0.000005138384],"category_scores_gemma":[0.00001333996,0.00009818343,0.00004498834,0.000103486,0.00003468827,0.00001630487,0.00001096935,0.00007191702,4.667282e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003957734,"about_ca_system_score_gemma":0.00005607862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001579519,"about_ca_topic_score_gemma":0.0001239709,"domain_scores_codex":[0.9992369,0.00004692803,0.0002861154,0.00024379,0.00009789105,0.00008840765],"domain_scores_gemma":[0.999752,0.00002341989,0.00004116856,0.0001119002,0.00004236492,0.0000291866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000253494,0.00006265599,0.05134169,0.00004849912,0.00001392803,1.484699e-7,0.0001044555,0.0029845,0.9435943,0.001357856,0.000005006401,0.0004615897],"study_design_scores_gemma":[0.00097983,0.0001051765,0.09474311,0.00007076793,0.00002643306,0.000001328169,0.00004529977,0.01533092,0.8848245,0.003160303,0.000493366,0.0002189607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9060106,0.004876819,0.08843441,0.0002165019,0.0001529563,0.0001940718,0.00006756688,0.000009036567,0.00003803426],"genre_scores_gemma":[0.9334111,0.0001856856,0.06537904,0.00001751078,0.0001056344,0.00001271612,0.000826776,0.00001708764,0.00004442377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05876981,"threshold_uncertainty_score":0.4003804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02219152057208754,"score_gpt":0.3080927208182486,"score_spread":0.2859012002461611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}