{"id":"W4403249628","doi":"10.1038/s41398-024-03139-9","title":"Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder","year":2024,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Plan Nacional sobre Drogas; Ministerio de Sanidad, Servicios Sociales e Igualdad; Institució Catalana de Recerca i Estudis Avançats; Agència de Gestió d'Ajuts Universitaris i de Recerca; Fundació la Marató de TV3; Generalitat de Catalunya; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Ministerio de Ciencia, Innovación y Universidades","keywords":"DNA methylation; Gene expression profiling; Omics; Gene; Computational biology; Human genome; Gene expression; Profiling (computer programming); Methylation; Biology; Bioinformatics; Genetics; Medicine; Genome; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003512879,0.0002438842,0.000529149,0.001052662,0.0003055837,0.0004167125,0.0001753109,0.0002447179,0.001045767],"category_scores_gemma":[0.0004620221,0.0001259315,0.0004075591,0.001070934,0.000135223,0.0001376287,0.0005081652,0.0002685253,0.000154569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000229042,"about_ca_system_score_gemma":0.000264296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00275948,"about_ca_topic_score_gemma":0.00568921,"domain_scores_codex":[0.9997285,0.00004470678,0.00002138323,0.0001183719,0.00004916536,0.00003789123],"domain_scores_gemma":[0.9997907,0.00005087968,0.00006572017,0.00002920972,0.0000404419,0.00002316972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001436521,0.00009808411,0.4517527,0.0005106648,0.001346341,0.0004410598,0.0003737394,0.002094155,0.4885248,0.0003365611,0.001528245,0.05155727],"study_design_scores_gemma":[0.00001738107,0.0001456279,0.9735097,0.00003328482,0.0003835363,0.0006658093,0.0002320808,0.003078965,0.01825751,0.0005978565,0.003058183,0.00002004801],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737564,0.003852351,0.00583119,0.0003219056,0.00002270335,0.0000400711,0.01528509,0.00009181303,0.0007983487],"genre_scores_gemma":[0.980109,0.001331984,0.007163101,0.0002273757,0.00002151154,0.00007094771,0.01020757,0.00004228384,0.0008262456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00275948,"threshold_uncertainty_score":0.005486786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02219152057208754,"score_gpt":0.3080927208182486,"score_spread":0.2859012002461611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}