{"id":"W4403252024","doi":"10.3390/genes15101305","title":"PERM1—An Emerging Transcriptional Regulator of Mitochondrial Biogenesis: A Systematic Review","year":2024,"lang":"en","type":"review","venue":"Genes","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Queen's University","funders":"","keywords":"Regulator; Mitochondrial biogenesis; Biogenesis; Biology; Computational biology; Cell biology; Transcriptional regulation; Mitochondrion; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002819995,0.000491334,0.002011118,0.0001686324,0.00005406264,0.00002192504,0.0004020087,0.000505772,0.0001306707],"category_scores_gemma":[0.00009465086,0.0003658708,0.001205996,0.0002506816,0.00006999778,0.00000380086,0.00007167434,0.0001372613,0.0001099077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001812197,"about_ca_system_score_gemma":0.0003160766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004833258,"about_ca_topic_score_gemma":0.00001246127,"domain_scores_codex":[0.997139,0.0005026209,0.001151352,0.0007211561,0.0002368158,0.0002490869],"domain_scores_gemma":[0.998523,0.00001525309,0.0003833474,0.0008403207,0.0001215028,0.0001165555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001309067,0.0000398816,1.183168e-7,0.9692398,0.0004967315,0.000007905497,0.00001642736,4.27597e-7,0.01288188,0.0001989896,0.003817538,0.01328723],"study_design_scores_gemma":[0.0000937748,0.0001435183,3.744886e-8,0.1682809,0.005504447,0.0002444485,0.00001122441,0.000001035724,0.000254637,0.000009983653,0.8251096,0.0003463398],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000006784161,0.9950128,0.0002750453,0.00002249736,0.002705967,0.001540314,0.0003328264,0.00002911284,0.00007466941],"genre_scores_gemma":[7.353152e-7,0.9935927,0.000579033,0.0001153243,0.001503221,0.000505927,0.00142217,0.00008664765,0.002194271],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.821292,"threshold_uncertainty_score":0.9998793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04384208523686296,"score_gpt":0.3323783846352408,"score_spread":0.2885362993983778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}