{"id":"W4403255336","doi":"10.1007/s10719-024-10169-4","title":"Production of Domain 9 from the cation-independent mannose-6-phosphate receptor fused with an Fc domain","year":2024,"lang":"en","type":"article","venue":"Glycoconjugate Journal","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Glycomics Network; Japan Society for the Promotion of Science; National Natural Science Foundation of China; Gifu University; Jiangnan University; National Institute of Advanced Industrial Science and Technology","keywords":"Mannose; Golgi apparatus; Lysosome; Mannose 6-phosphate receptor; Mannose 6-phosphate; Glycan; Endoplasmic reticulum; Enzyme; Biochemistry; Mannose receptor; Receptor; Cell biology; Fusion protein; Biology; Transfection; Recombinant DNA; Chemistry; Glycoprotein; Gene; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003095708,0.0004856921,0.0002479082,0.0002541702,0.0001736307,0.0002771195,0.0005745142,0.000624645,0.001128317],"category_scores_gemma":[0.0002115809,0.0001829293,0.0005649517,0.0002460819,0.0002543292,0.0001964818,0.0004135741,0.0008910278,0.000805525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004604086,"about_ca_system_score_gemma":0.0002148296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009249922,"about_ca_topic_score_gemma":0.0004558731,"domain_scores_codex":[0.9997327,0.00005055673,0.00002889101,0.00006316188,0.00006657786,0.00005811047],"domain_scores_gemma":[0.9998645,0.00002810707,0.00003689337,0.0000273331,0.00001460309,0.00002845577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004008682,0.00002089956,0.00006293288,0.00002190798,0.000004764458,0.00006714433,0.000007213718,0.00006755752,0.9992805,0.00008100217,0.0000273726,0.0003184908],"study_design_scores_gemma":[0.00001950864,0.0001558714,0.0007809032,0.000005815703,0.0000164238,0.0003068565,0.0000100731,0.0009139284,0.9937389,0.00002456881,0.0040221,0.000005006947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974551,0.001463753,0.01951946,0.0002920691,0.0001571534,0.0001735169,0.001607866,0.0001633331,0.002071833],"genre_scores_gemma":[0.9740784,0.0006675204,0.01673932,0.00009127338,0.00002493501,0.00007897946,0.004519998,0.00004303927,0.003756561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001128317,"threshold_uncertainty_score":0.003774583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654947752733059,"score_gpt":0.282805427065533,"score_spread":0.2662559495382024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}