{"id":"W4403262182","doi":"10.1186/s13100-024-00333-w","title":"A T cell receptor specific for an HLA-A*03:01-restricted epitope in the endogenous retrovirus ERV-K-Env exhibits limited recognition of its cognate epitope","year":2024,"lang":"en","type":"article","venue":"Mobile DNA","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; National Cancer Institute; Children's National Hospital; Cosmos Club Foundation; U.S. Department of Defense","keywords":"Epitope; Biology; Retrovirus; Endogenous retrovirus; Human leukocyte antigen; Receptor; Virology; Genetics; Antibody; Antigen; Gene; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537639,0.0002643293,0.0002010067,0.0001091124,0.00012616,0.0003440265,0.0001966272,0.0003047681,0.00184182],"category_scores_gemma":[0.0001541085,0.0001111663,0.0001741384,0.00009849562,0.0001944346,0.0001862375,0.0001613695,0.000529037,0.000614344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033137,"about_ca_system_score_gemma":0.0001284848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002200795,"about_ca_topic_score_gemma":0.000230176,"domain_scores_codex":[0.9998012,0.00004715894,0.00001200289,0.00005030452,0.00002763475,0.00006161111],"domain_scores_gemma":[0.9999011,0.00003635543,0.00001831072,0.00001881171,0.000008795012,0.00001659596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004446356,0.00002897855,0.000379001,0.00001270108,0.000002368933,0.0000675477,0.00001061624,0.00002822957,0.9986362,0.00008244457,0.00001329019,0.0006942549],"study_design_scores_gemma":[0.00004351419,0.001198999,0.00833392,0.000008416188,0.00003479413,0.00291691,0.00009314988,0.001785492,0.9825678,0.0001127951,0.002897145,0.000007040148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970208,0.0003796889,0.001523116,0.00002167316,0.000007476028,0.00001453763,0.00004283342,0.00002247435,0.0009675124],"genre_scores_gemma":[0.9985566,0.0001114944,0.0004691282,0.00001797099,0.000003501265,0.00000680619,0.00008450233,0.000004801708,0.0007452526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00184182,"threshold_uncertainty_score":0.006161451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04117880275209982,"score_gpt":0.2416732415615238,"score_spread":0.200494438809424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}