{"id":"W4403267409","doi":"10.1016/j.mcpro.2024.100855","title":"Retinal Proteome Profiling of Inherited Retinal Degeneration Across Three Different Mouse Models Suggests Common Drug Targets in Retinitis Pigmentosa","year":2024,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Eye Institute; Terveyden Tutkimuksen Toimikunta; National Institutes of Health; Business Finland; De Blindas Vänner; University of California, Irvine; University of Ottawa; Sigrid Juséliuksen Säätiö; Silmä- ja kudospankkisäätiö; Emil Aaltosen Säätiö; Research to Prevent Blindness; Päivikki ja Sakari Sohlbergin Säätiö; Canadian Institute for Advanced Research; Academy of Finland","keywords":"Retinitis pigmentosa; Retinal degeneration; Retinal; Proteome; Gene therapy of the human retina; Drug; Biology; Profiling (computer programming); Computational biology; Ophthalmology; Genetics; Medicine; Pharmacology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003697727,0.0004354537,0.0003160682,0.0009305323,0.0003083819,0.0005066076,0.0002521968,0.0005466674,0.0006526849],"category_scores_gemma":[0.0002228685,0.0002078447,0.0006727422,0.0004545652,0.0002835788,0.0003179553,0.0003717715,0.0009285352,0.0002692526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003172347,"about_ca_system_score_gemma":0.0002024815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008957547,"about_ca_topic_score_gemma":0.001164598,"domain_scores_codex":[0.9995981,0.00003942475,0.00005865762,0.0001390459,0.0001155101,0.00004933384],"domain_scores_gemma":[0.9996495,0.00002895102,0.0001528694,0.00004319206,0.00005921788,0.00006617538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001563726,0.00002667187,0.0009098941,0.00004381277,0.00001983953,0.00005894163,0.0000284343,0.00004005483,0.9974828,0.00006213164,0.00006219441,0.001108896],"study_design_scores_gemma":[0.00004000347,0.0007591662,0.08435071,0.00005212454,0.0001928581,0.001462045,0.0002000884,0.001501048,0.9063872,0.0002361246,0.004780515,0.00003814065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780488,0.002191568,0.01257129,0.0002436722,0.00007358602,0.0000828652,0.005147362,0.0003407581,0.001300156],"genre_scores_gemma":[0.9627286,0.003281299,0.02250608,0.0004515775,0.00002227519,0.0004021701,0.006502279,0.0001947233,0.003911143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009305323,"threshold_uncertainty_score":0.002301693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01095205559374446,"score_gpt":0.2442512761932568,"score_spread":0.2332992205995124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}