{"id":"W4403275112","doi":"10.2139/ssrn.4968921","title":"Functionalized Nanodiamonds as Sirna Delivery Vectors for Hepatocellular Carcinoma: In Vitro Evaluation of Safety, Intracellular Distribution, and Nucleic Acid Transfection Efficiency","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland; University of Saskatchewan","funders":"","keywords":"Nucleic acid; Transfection; Intracellular; In vitro; Hepatocellular carcinoma; Distribution (mathematics); Small interfering RNA; Chemistry; Cell biology; Cancer research; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003826868,0.0003094861,0.0002699798,0.0002245694,0.0001500187,0.0003389504,0.0001744957,0.0004690545,0.0004057552],"category_scores_gemma":[0.0003720882,0.000189655,0.0002386655,0.0002173004,0.0002140983,0.000208106,0.0001725197,0.0002403812,0.000205484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005489751,"about_ca_system_score_gemma":0.0002763291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001458148,"about_ca_topic_score_gemma":0.001588194,"domain_scores_codex":[0.9997759,0.00005762875,0.00002018523,0.00004815591,0.0000672117,0.00003086549],"domain_scores_gemma":[0.9998149,0.00005406862,0.0000488761,0.00001805295,0.00004312141,0.00002097075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009090628,0.000009412586,0.00004956352,0.00002519443,0.000004410253,0.00001165475,0.00001337868,0.0001092908,0.9989485,0.00005401213,0.00001050066,0.0006732572],"study_design_scores_gemma":[0.000003331888,0.00009808812,0.0001907621,0.000001214903,0.000008721687,0.00001486561,0.000003036112,0.000410349,0.998993,0.000008897796,0.000265382,0.000002312159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873351,0.001545532,0.009640518,0.00003880888,0.00002684851,0.00006884772,0.0002332487,0.00007575893,0.001035247],"genre_scores_gemma":[0.9864694,0.0008584954,0.008924228,0.0000295225,0.000005192077,0.00004578932,0.000350448,0.00004453622,0.003272367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001458148,"threshold_uncertainty_score":0.00398308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016352180944497,"score_gpt":0.2441644670526035,"score_spread":0.2340009452431585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}