{"id":"W4403276034","doi":"10.1038/s41467-024-53068-w","title":"Tankyrase inhibition promotes endocrine commitment of hPSC-derived pancreatic progenitors","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; McMaster University; University of Toronto; University Health Network","funders":"CIHR Skin Research Training Centre; Banting and Best Diabetes Centre, University of Toronto; Eli Lilly Canada; Government of Canada; Natural Sciences and Engineering Research Council of Canada; Juvenile Diabetes Research Foundation United States of America; Toronto General and Western Hospital Foundation; Juvenile Diabetes Research Foundation Canada; Leona M. and Harry B. Helmsley Charitable Trust; Toronto General Hospital Research Institute, University Health Network; Canadian Society of Transplantation; Eli Lilly and Company","keywords":"Endocrine system; Progenitor cell; Progenitor; Cell biology; Enteroendocrine cell; Biology; Endocrinology; Stem cell; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001487776,0.0002282375,0.0001573053,0.0001675669,0.0001138264,0.0003071504,0.0002084665,0.0002062802,0.001478684],"category_scores_gemma":[0.00015019,0.0001078776,0.0002261966,0.000131777,0.0001439187,0.0001551357,0.0002568991,0.0007561478,0.0005024784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002344597,"about_ca_system_score_gemma":0.0002662338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001385244,"about_ca_topic_score_gemma":0.001486197,"domain_scores_codex":[0.9998801,0.00001361727,0.00001641391,0.00002755032,0.00003719359,0.00002505062],"domain_scores_gemma":[0.9998722,0.00003545613,0.00002807034,0.00001512682,0.00001567932,0.00003333162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008545714,0.00001873392,0.0001128888,0.00003213791,0.000004624799,0.00005231279,0.00001582009,0.00009464134,0.9976539,0.0000799495,0.0001238736,0.001725646],"study_design_scores_gemma":[0.00001070051,0.00008292535,0.00100888,0.000003783015,0.000007380308,0.0000870511,0.00001006948,0.000550297,0.9959001,0.00002808805,0.002308143,0.000002504838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843365,0.00219386,0.006092426,0.0003038314,0.00009057482,0.00004254162,0.001006585,0.0003258842,0.005607879],"genre_scores_gemma":[0.9871203,0.001327536,0.003630432,0.0001545472,0.00001892931,0.00004207421,0.001050104,0.00005791182,0.006598108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001478684,"threshold_uncertainty_score":0.004946649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258273514268515,"score_gpt":0.3124957740687351,"score_spread":0.28991303892605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}