{"id":"W4403282574","doi":"10.1186/s13059-024-03415-3","title":"Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation","year":2024,"lang":"en","type":"article","venue":"Genome biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"National Institute of Allergy and Infectious Diseases; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; National Institute of General Medical Sciences; McGill University","keywords":"Biology; Methylation; Methyltransferase; Genetics; Human genetics; Computational biology; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005032232,0.0001554313,0.0002715706,0.0001160205,0.00009096991,0.00002561487,0.0001114661,0.0001885673,0.0000162869],"category_scores_gemma":[0.0004076117,0.0001250935,0.00008728667,0.0001786952,0.00008165556,0.000003910448,0.00009810549,0.00006817808,0.00001533987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002990085,"about_ca_system_score_gemma":0.00007248623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002026123,"about_ca_topic_score_gemma":0.00002663257,"domain_scores_codex":[0.998777,0.0001995645,0.0003969314,0.000361753,0.00005742754,0.0002073045],"domain_scores_gemma":[0.9992305,0.0001275469,0.00008721392,0.0002857638,0.0001761682,0.00009278709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000146702,0.00002033681,0.0005450834,0.0005600618,0.0001160742,5.2695e-7,0.0002022747,0.0000372626,0.9956082,0.002103862,0.00005979531,0.0007319234],"study_design_scores_gemma":[0.001876208,0.00438515,0.08207918,0.001390519,0.000787985,0.00007101533,0.0007146662,0.002642324,0.7414416,0.02460687,0.1379835,0.002020986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9147505,0.02932589,0.05281695,0.0005910626,0.0003266321,0.0006988595,0.0008535634,0.00003004683,0.0006065567],"genre_scores_gemma":[0.9976612,0.0003070386,0.0005466037,0.00004845091,0.0002006372,0.00007049166,0.0007184554,0.00001725217,0.0004298947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2541665,"threshold_uncertainty_score":0.5101163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026105090664309,"score_gpt":0.2829386532281336,"score_spread":0.2726776023214905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}