{"id":"W4403286057","doi":"10.1016/s2468-1253(24)00246-2","title":"Denifanstat for the treatment of metabolic dysfunction-associated steatohepatitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2b trial","year":2024,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Steatohepatitis; Clinical endpoint; Placebo; Internal medicine; Fatty liver; Fibrosis; Clinical trial; Gastroenterology; Randomized controlled trial; Disease; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005377371,0.0005198405,0.002301534,0.0002102298,0.0002581522,0.00004988049,0.0002593592,0.0002222325,0.0002234904],"category_scores_gemma":[0.00006995238,0.0002768394,0.001194927,0.0001880956,0.0003775771,0.00007282288,0.00003843755,0.0002396026,0.0000449162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021489,"about_ca_system_score_gemma":0.0002464861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003993968,"about_ca_topic_score_gemma":0.002205328,"domain_scores_codex":[0.9965662,0.0005631527,0.0009878745,0.0006740231,0.0002762249,0.000932494],"domain_scores_gemma":[0.9963907,0.002129523,0.0003665816,0.0007131684,0.0002005604,0.0001994883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9010808,0.005066142,0.07368396,0.00006410281,0.01269707,0.0001880084,0.0005716326,0.00002278702,0.00004176013,0.0003234319,0.002786444,0.003473879],"study_design_scores_gemma":[0.9549602,0.009397341,0.001923482,0.00005305883,0.0133368,0.0001170139,0.0001675982,0.007091236,0.0001622979,0.00005935184,0.01260093,0.0001306774],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659842,0.01197265,0.0008984121,0.005866999,0.002321163,0.01233624,0.0003905122,0.0001298201,0.0001000288],"genre_scores_gemma":[0.9812044,0.004768088,0.00006864462,0.0010826,0.0009114767,0.01129556,0.0002949361,0.00005504889,0.0003192734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07176048,"threshold_uncertainty_score":0.9999683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04146828469596038,"score_gpt":0.3287970167548783,"score_spread":0.2873287320589179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}