{"id":"W4403286057","doi":"10.1016/s2468-1253(24)00246-2","title":"Denifanstat for the treatment of metabolic dysfunction-associated steatohepatitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2b trial","year":2024,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Steatohepatitis; Clinical endpoint; Placebo; Internal medicine; Fatty liver; Fibrosis; Clinical trial; Gastroenterology; Randomized controlled trial; Disease; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003474243,0.00165535,0.002641128,0.0005337521,0.0004869674,0.0008662529,0.0008690113,0.00187737,0.006954486],"category_scores_gemma":[0.001833623,0.0006942879,0.001566611,0.0004845853,0.0008742748,0.0009346286,0.0004187647,0.001772029,0.0009938736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007472532,"about_ca_system_score_gemma":0.001392339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008761528,"about_ca_topic_score_gemma":0.002492595,"domain_scores_codex":[0.9990602,0.0005505279,0.00005814819,0.0001440802,0.00008088073,0.0001061427],"domain_scores_gemma":[0.9992142,0.0001596877,0.0002159706,0.00006791496,0.00009044691,0.0002518154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9778726,0.004206624,0.0004504233,0.0009987715,0.0007739795,0.00003059018,0.00003797534,0.0001983111,0.002554976,0.00007109121,0.000930286,0.0118743],"study_design_scores_gemma":[0.981656,0.01659941,0.0008480066,0.0000259438,0.0001919382,0.00001638527,0.000006106832,0.0001086902,0.0001310277,0.0000345725,0.0003765145,0.000005354736],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647381,0.017283,0.00118456,0.00188963,0.0009100745,0.00872981,0.002396348,0.0001797949,0.002688776],"genre_scores_gemma":[0.9629202,0.009956556,0.00368071,0.002631418,0.0007430718,0.01244172,0.00231023,0.00004168802,0.005274359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006954486,"threshold_uncertainty_score":0.02326506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04146828469596038,"score_gpt":0.3287970167548783,"score_spread":0.2873287320589179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}