{"id":"W4403287054","doi":"10.1016/j.ekir.2024.10.004","title":"Study Design and Baseline Characteristics of ALIGN, a Randomized Controlled Study of Atrasentan in Patients With IgA Nephropathy","year":2024,"lang":"en","type":"article","venue":"Kidney International Reports","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Novartis","keywords":"Medicine; Proteinuria; Placebo; Renal function; Urology; Internal medicine; Randomized controlled trial; Population; Kidney disease; Nephropathy; Creatinine; Adverse effect; Gastroenterology; Kidney; Endocrinology; Pathology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007245097,0.002400751,0.004820386,0.0006899112,0.0009413644,0.001336127,0.0008050542,0.002464684,0.02154037],"category_scores_gemma":[0.006448213,0.0009573728,0.002397266,0.001110849,0.001067727,0.001339691,0.000598543,0.002316612,0.001801273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007975355,"about_ca_system_score_gemma":0.002438189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007427899,"about_ca_topic_score_gemma":0.001866819,"domain_scores_codex":[0.9941637,0.003516454,0.0005396327,0.0007453347,0.0004520539,0.0005829001],"domain_scores_gemma":[0.9980224,0.0006158093,0.0004897125,0.0001366169,0.0002340757,0.0005014002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9642034,0.006308097,0.003268417,0.003147968,0.002959543,0.00009582082,0.00007575072,0.0004050033,0.001216575,0.0006015291,0.00316423,0.01455373],"study_design_scores_gemma":[0.9307928,0.0529102,0.005705941,0.0003007052,0.002327853,0.00004352327,0.00004633165,0.0004031716,0.0002342464,0.0007518631,0.006450029,0.00003342938],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.4696339,0.02653945,0.01037833,0.00452319,0.003362181,0.445176,0.02213322,0.0004503099,0.01780338],"genre_scores_gemma":[0.4871907,0.005397159,0.01138452,0.005847285,0.001218035,0.479215,0.003290664,0.00005150854,0.006405072],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.02154037,"threshold_uncertainty_score":0.07205975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007611411470886118,"score_gpt":0.2645753752520416,"score_spread":0.2569639637811555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}