{"id":"W4403287466","doi":"10.1016/j.jlr.2024.100667","title":"Apolipoprotein B gene expression and regulation in relation to Alzheimer’s disease pathophysiology","year":2024,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; Fonds de Recherche du Québec - Santé; National Research Council Canada; Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Fondation Jean-Louis Lévesque; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; National Institute on Aging; Eli Lilly and Company; F. Hoffmann-La Roche","keywords":"Pathophysiology; Apolipoprotein B; Disease; Gene; Gene expression; Alzheimer's disease; Biology; Genetics; Medicine; Internal medicine; Bioinformatics; Endocrinology; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001202828,0.0001010372,0.0002220946,0.000982313,0.00008092948,0.0000515903,0.0000750312,0.00007553552,0.0001000274],"category_scores_gemma":[0.0003297709,0.00007171794,0.0000792823,0.000540522,0.00008275046,0.0002301939,0.00008966935,0.0005294309,0.00006103006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001325958,"about_ca_system_score_gemma":0.0005627325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002276405,"about_ca_topic_score_gemma":0.000001632921,"domain_scores_codex":[0.9978242,0.0003523919,0.0003529598,0.000232892,0.0008954472,0.0003421244],"domain_scores_gemma":[0.9985324,0.0001945624,0.00004464451,0.0001886522,0.0003110672,0.0007286347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02704526,0.002671994,0.10755,0.001090396,0.004149646,0.01139758,0.001992383,0.000385339,0.6889331,0.001428329,0.0237471,0.1296089],"study_design_scores_gemma":[0.002990144,0.002472786,0.9547472,0.002501864,0.0002484886,0.0001618463,0.0001436565,0.002161809,0.02413932,0.00810869,0.002128526,0.0001956751],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970593,0.02394236,0.00007707455,0.004417657,0.0001203355,0.0006376366,0.00000887041,0.00001249252,0.0001906217],"genre_scores_gemma":[0.9973431,0.0008415364,0.0009294003,0.00003645116,0.0006892369,0.00002987101,0.00001274412,0.00002146932,0.00009621968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8471972,"threshold_uncertainty_score":0.2924573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07254665818928945,"score_gpt":0.4018846977349579,"score_spread":0.3293380395456685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}