{"id":"W4403287466","doi":"10.1016/j.jlr.2024.100667","title":"Apolipoprotein B gene expression and regulation in relation to Alzheimer’s disease pathophysiology","year":2024,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; Fonds de Recherche du Québec - Santé; National Research Council Canada; Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Fondation Jean-Louis Lévesque; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; National Institute on Aging; Eli Lilly and Company; F. Hoffmann-La Roche","keywords":"Pathophysiology; Apolipoprotein B; Disease; Gene; Gene expression; Alzheimer's disease; Biology; Genetics; Medicine; Internal medicine; Bioinformatics; Endocrinology; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001556395,0.0001321304,0.0001207657,0.000429643,0.0001312841,0.0003411589,0.0001171444,0.0001509917,0.0004561291],"category_scores_gemma":[0.0002468633,0.00008587699,0.00008925949,0.00036462,0.0002545815,0.0001018805,0.0001180025,0.0001691831,0.0001425479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000251902,"about_ca_system_score_gemma":0.0001404243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002340048,"about_ca_topic_score_gemma":0.001123761,"domain_scores_codex":[0.999912,0.00002439324,0.000004067823,0.00002850357,0.00001759343,0.00001341391],"domain_scores_gemma":[0.9998943,0.00002708057,0.00002930371,0.000009202863,0.00002418163,0.00001595369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002572978,0.0003159459,0.4929615,0.0001855192,0.0001777258,0.001457929,0.001270701,0.0003171498,0.4025662,0.001593581,0.001274139,0.09530653],"study_design_scores_gemma":[0.00001535476,0.0001508829,0.9917763,0.00001159963,0.00002364599,0.0004750996,0.0002076451,0.00018886,0.005242462,0.000602984,0.001298157,0.000007047305],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924401,0.00518204,0.0004659164,0.0002313626,0.00001212444,0.000005162322,0.0001246826,0.000008182439,0.001530444],"genre_scores_gemma":[0.9947355,0.003214007,0.000371885,0.00008798573,0.00002897543,0.00001146301,0.0001319853,0.00000504296,0.001413187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002340048,"threshold_uncertainty_score":0.004652798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07254665818928945,"score_gpt":0.4018846977349579,"score_spread":0.3293380395456685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}