{"id":"W4403292881","doi":"10.26508/lsa.202302505","title":"NAD <sup>+</sup> depletion is central to placental dysfunction in an inflammatory subclass of preeclampsia","year":2024,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Subclass; Preeclampsia; NAD+ kinase; Placenta; Chemistry; Medicine; Immunology; Pregnancy; Biology; Biochemistry; Antibody; Fetus; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002771711,0.0001408801,0.0002178755,0.000217425,0.0001670817,0.0003159925,0.0001523784,0.0002035564,0.001180615],"category_scores_gemma":[0.0003055318,0.0001164316,0.0001199346,0.0002112844,0.0003169789,0.0001766626,0.0002749722,0.0004382927,0.0001348428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002551428,"about_ca_system_score_gemma":0.0002954485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005045552,"about_ca_topic_score_gemma":0.0004798216,"domain_scores_codex":[0.9999174,0.00002719808,0.000009215337,0.00001713288,0.00001566337,0.00001344795],"domain_scores_gemma":[0.9998751,0.00001865071,0.00004904574,0.00001587697,0.00001049746,0.00003092739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006888472,0.0004658789,0.06151545,0.000581402,0.0001165434,0.004355002,0.0006185576,0.0002008162,0.8471731,0.003044987,0.0008453982,0.07419439],"study_design_scores_gemma":[0.0002809851,0.004965953,0.6619469,0.0001694049,0.0002319798,0.01420774,0.001394044,0.0009887347,0.287733,0.004688407,0.02336304,0.00002980244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978994,0.01250794,0.002235685,0.0009302108,0.00005173977,0.00005521065,0.0002105452,0.00004303617,0.004971627],"genre_scores_gemma":[0.9923127,0.005536544,0.0007860064,0.0001414177,0.00002647177,0.00002386943,0.00009759848,0.000003525331,0.001071679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180615,"threshold_uncertainty_score":0.003949583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02163598119670154,"score_gpt":0.2864206402328748,"score_spread":0.2647846590361733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}