{"id":"W4403297265","doi":"10.1111/1751-7915.70030","title":"Understanding the impact of the gut microbiome on opioid use disorder: Pathways, mechanisms, and treatment insights","year":2024,"lang":"en","type":"review","venue":"Microbial Biotechnology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"","keywords":"Opioid use disorder; Microbiome; Gut microbiome; Addiction; Psychological intervention; Leverage (statistics); Opioid; Medicine; Bioinformatics; Biology; Psychiatry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001079516,0.0006789286,0.0009908926,0.0002610357,0.000266517,0.00006806006,0.0005949663,0.001521085,0.00000727204],"category_scores_gemma":[0.00002596884,0.0003214281,0.0007957582,0.0003955727,0.0005188388,0.000003264678,0.0005553453,0.0005348078,0.00002170437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004022945,"about_ca_system_score_gemma":0.0006215671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002465055,"about_ca_topic_score_gemma":0.0003285408,"domain_scores_codex":[0.9979777,0.0001903677,0.0005317993,0.0007741884,0.00006129855,0.0004646801],"domain_scores_gemma":[0.9984996,0.00003877574,0.0003301591,0.001053075,0.00002413383,0.00005430984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004521157,0.0002178193,0.000002130964,0.001736614,0.001089295,0.00001115101,0.000152619,0.000002141823,0.9241005,0.00548625,0.00519396,0.06196238],"study_design_scores_gemma":[0.000377823,0.001264743,0.000005257527,0.001780333,0.0006115295,0.0002881361,0.00005169114,0.000001139649,0.0109311,0.000386835,0.9838634,0.0004379803],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01063653,0.9857662,0.0001630862,0.0002867229,0.0004945784,0.001542734,0.001044596,0.00004645362,0.00001915402],"genre_scores_gemma":[0.01101802,0.9880608,0.0000745494,0.0000704251,0.00008820535,0.0000326848,0.0002925802,0.00008596302,0.0002767962],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9786695,"threshold_uncertainty_score":0.9999238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06325136311412015,"score_gpt":0.3006520119294803,"score_spread":0.2374006488153601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}