{"id":"W4403303732","doi":"10.1128/spectrum.01474-24","title":"<i>In vitro</i> activity assessment of cefiderocol against Enterobacterales, <i>Pseudomonas aeruginosa,</i> and <i>Acinetobacter</i> spp., including β-lactam nonsusceptible molecularly characterized isolates, collected from 2020 to 2021 in the United States and European hospitals","year":2024,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; U.S. Food and Drug Administration; Astellas Pharma; Basilea Pharmaceutica; Ohio State University; Nabriva Therapeutics; Pfizer; Entasis Therapeutics; Wockhardt; Mundipharma International; Zoetis; Menarini Group; McGill University; Roche; Cidara Therapeutics; Medpace; Carnegie Mellon University; TenNor Therapeutics; Harvard University; National Institutes of Health; Meiji Seika Pharma; Shionogi; National Cancer Institute; Gilead Sciences; Dr. Falk Pharma","keywords":"Microbiology; Pseudomonas aeruginosa; Acinetobacter baumannii; Cephalosporin; Biology; Acinetobacter calcoaceticus; Antimicrobial; Ceftazidime/avibactam; Carbapenem; Acinetobacter; Imipenem; Klebsiella pneumoniae; Meropenem; Escherichia coli; Ceftazidime; Antibiotic resistance; Antibiotics; Bacteria; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000463546,0.0004157568,0.0005325495,0.000223251,0.00007956252,0.0001545521,0.0003420324,0.0001957634,0.00002495439],"category_scores_gemma":[0.00003560811,0.0003551515,0.00008211861,0.0005345247,0.000215206,0.00003011379,0.0003856898,0.0003647197,0.000007544116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007090817,"about_ca_system_score_gemma":0.00008167198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004164715,"about_ca_topic_score_gemma":0.0005465404,"domain_scores_codex":[0.9973136,0.0006831923,0.0005412704,0.0008701907,0.00006923865,0.0005224842],"domain_scores_gemma":[0.999146,0.0001262597,0.0001631703,0.000436216,0.00003872981,0.00008961705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003928309,0.0001136471,0.01992095,0.00005966527,0.0001090483,0.000120893,0.0002771106,0.000004738296,0.9778588,0.000005804615,0.0009957127,0.0001408464],"study_design_scores_gemma":[0.001953448,0.0006072078,0.1821558,0.000337862,0.00005360467,0.00009138605,0.0002080792,0.0001723186,0.8004792,0.0000286834,0.01328066,0.0006316825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951976,0.0006451668,0.0003109528,0.001986895,0.0001967933,0.0009016059,0.0006134807,0.00001730099,0.0001302135],"genre_scores_gemma":[0.9943336,0.001784146,0.0009086058,0.001319,0.0001047115,0.00002731023,0.001401921,0.00005107605,0.0000696295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1773795,"threshold_uncertainty_score":0.99989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005618348930727269,"score_gpt":0.2396254263705721,"score_spread":0.2340070774398448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}