{"id":"W4403304599","doi":"10.3389/fchem.2024.1436008","title":"A sustainable protocol for the synthesis of N-acyl tryptamines, a class of potential gut microbiota-derived endocannabinoid-like mediators","year":2024,"lang":"en","type":"article","venue":"Frontiers in Chemistry","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Tryptamines; Chemistry; Endocannabinoid system; Acylation; Simplicity; Organic chemistry; Biochemistry; Tryptamine; Physics; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004026097,0.0007230665,0.0003450867,0.0003375338,0.0003032601,0.0002415688,0.0004943965,0.0005843235,0.002143849],"category_scores_gemma":[0.0003488686,0.0001999462,0.0003387531,0.0003154528,0.0002506789,0.0005391694,0.0005573653,0.00111417,0.001555255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002553797,"about_ca_system_score_gemma":0.0008885036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005282104,"about_ca_topic_score_gemma":0.00113946,"domain_scores_codex":[0.9997578,0.00003104876,0.00002886252,0.0000586784,0.00005917519,0.00006431834],"domain_scores_gemma":[0.9998977,0.00001653973,0.00002255405,0.00001726103,0.0000218859,0.00002401068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000141545,0.0001229601,0.0002140469,0.0009172834,0.00007125089,0.00101598,0.000185828,0.001015301,0.9587126,0.004178146,0.001222649,0.03220252],"study_design_scores_gemma":[0.00006977902,0.0009467736,0.0007487528,0.00004849135,0.00005261092,0.0012705,0.00007303787,0.001769655,0.9605742,0.001640674,0.03273466,0.00007105622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.4904677,0.01622308,0.4461063,0.001644609,0.0009345334,0.001985711,0.003410032,0.001047915,0.03818009],"genre_scores_gemma":[0.9032977,0.01220637,0.07299399,0.0003760618,0.00009587807,0.0007621992,0.001488023,0.0001160516,0.008663721],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002143849,"threshold_uncertainty_score":0.007171929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005371577388370697,"score_gpt":0.2370843844000336,"score_spread":0.2317128070116629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}