{"id":"W4403307352","doi":"10.1089/crispr.2024.0032","title":"Genome Editing in Apicomplexan Parasites: Current Status, Challenges, and Future Possibilities","year":2024,"lang":"en","type":"review","venue":"The CRISPR Journal","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"","keywords":"Genome editing; Current (fluid); Biology; Genome; Computational biology; Data science; Evolutionary biology; Computer science; Genetics; Gene; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00143438,0.0005196034,0.001405312,0.0004424584,0.0004320783,0.0001333075,0.0005210806,0.0003161486,0.000198402],"category_scores_gemma":[0.0001491633,0.0002750447,0.0003178235,0.0001675285,0.0004615182,0.0001007954,0.0005059481,0.00457351,0.0002846664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002563532,"about_ca_system_score_gemma":0.0003186924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001017433,"about_ca_topic_score_gemma":0.00006632271,"domain_scores_codex":[0.9965123,0.00123541,0.0007873881,0.00042893,0.0001068867,0.0009290981],"domain_scores_gemma":[0.9987224,0.0005022875,0.0003026323,0.0003350748,0.00007106442,0.00006656581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001201932,0.00004066073,0.000006326734,0.007872003,0.0006165319,0.00005538504,0.004959344,4.739248e-8,0.000005742041,0.0007774733,0.002398193,0.9832563],"study_design_scores_gemma":[0.0002279914,0.0000796376,0.0002151522,0.005074433,0.000411715,0.001550494,0.003995806,8.55033e-8,5.53036e-7,0.00100607,0.9871907,0.000247347],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001611648,0.9953825,8.59599e-7,0.0007068402,0.00272288,0.0004728865,0.0001611234,0.00003741189,0.0003542947],"genre_scores_gemma":[0.00005772856,0.9970875,0.00001018893,0.000009254921,0.002117176,0.0000558512,0.00005226366,0.00004943456,0.0005606291],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9847925,"threshold_uncertainty_score":0.9999702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1005851220005584,"score_gpt":0.3925633003242125,"score_spread":0.2919781783236541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}