{"id":"W4403321167","doi":"10.1016/s2665-9913(24)00223-6","title":"Efficacy and safety of a diffusion-based extended-release fluticasone propionate intra-articular injection (EP-104IAR) in knee osteoarthritis (SPRINGBOARD): a 24-week, multicentre, randomised, double-blind, vehicle-controlled, phase 2 trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aurinia (Canada)","funders":"Eupraxia Pharmaceuticals; Leeds Biomedical Research Centre; National Institute for Health and Care Research","keywords":"Osteoarthritis; Medicine; Double blind; Physical therapy; Fluticasone propionate; Knee pain; Physical medicine and rehabilitation; Surgery; Alternative medicine; Pathology; Corticosteroid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007410356,0.0003623884,0.001606765,0.0003058821,0.0001285417,0.00004818456,0.0001193748,0.0002468882,0.0001207831],"category_scores_gemma":[0.000484176,0.0002476117,0.0002498933,0.000362056,0.0002615601,0.00009622076,0.00006640428,0.0004931145,0.00003382229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008289393,"about_ca_system_score_gemma":0.0002137993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001123427,"about_ca_topic_score_gemma":0.0001531422,"domain_scores_codex":[0.9972023,0.0003855988,0.0009582033,0.0005418574,0.0003239037,0.0005881012],"domain_scores_gemma":[0.9980782,0.0009540489,0.0001956656,0.0004820768,0.0001073892,0.0001826207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9078336,0.00173534,0.0002542628,0.0003131287,0.0002247058,0.0003838468,0.0006839567,0.0000275553,0.006123321,0.001537533,0.00004647259,0.08083624],"study_design_scores_gemma":[0.9787362,0.00619374,0.0000846375,0.001187855,0.0005679285,0.0003346938,0.0001556321,0.00887789,0.002907172,0.0002071399,0.0005125444,0.0002345362],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824644,0.006937575,0.0003121551,0.001764234,0.001050068,0.007180335,0.00002189515,0.0001665953,0.0001027432],"genre_scores_gemma":[0.9977099,0.0006262525,0.0003038907,0.0001225379,0.0001488134,0.0008563369,0.00006331168,0.00004669394,0.0001222125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0806017,"threshold_uncertainty_score":0.9999976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02143904660275169,"score_gpt":0.2897269352380538,"score_spread":0.2682878886353021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}