{"id":"W4403324311","doi":"10.1101/2024.10.11.617870","title":"Cefepime-Taniborbactam and Ceftibuten-Ledaborbactam Maintain Activity Against KPC Variants that Lead to Ceftazidime-Avibactam Resistance","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Wellcome Trust","keywords":"Ceftazidime/avibactam; Cefepime; Ceftazidime; Medicine; Biology; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001172959,0.0003481024,0.0003404337,0.0001304897,0.00008245713,0.0002858221,0.0003059787,0.0002875465,0.0008628141],"category_scores_gemma":[0.0002674945,0.0001264852,0.000273555,0.0001921912,0.0001657645,0.0001619042,0.0001680535,0.0004867936,0.0002779345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002058046,"about_ca_system_score_gemma":0.0001857822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001129983,"about_ca_topic_score_gemma":0.001344081,"domain_scores_codex":[0.9997388,0.00003713511,0.00003229454,0.00004440563,0.00009392857,0.00005350281],"domain_scores_gemma":[0.9998523,0.00002695447,0.00003739953,0.00002416386,0.00002659107,0.00003254991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001855697,0.00009914046,0.0004610354,0.0000239997,0.00001210793,0.00004498211,0.00001172169,0.00007614379,0.9974639,0.00003271168,0.00003313988,0.001555342],"study_design_scores_gemma":[0.00001647955,0.0006513247,0.003597159,0.000003343364,0.00001093794,0.0002566609,0.00001758471,0.0004270804,0.9940525,0.0000131047,0.0009497397,0.000004143705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980043,0.0006076457,0.0005785964,0.00003631717,0.00001384456,0.0000178408,0.0002646518,0.00003049301,0.0004464378],"genre_scores_gemma":[0.9967147,0.0002364127,0.001191875,0.00002430684,0.000004113293,0.00001606889,0.0007436731,0.00001514356,0.001053705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129983,"threshold_uncertainty_score":0.002886355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073152678433491,"score_gpt":0.2284150073194539,"score_spread":0.217683480535119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}