{"id":"W4403329825","doi":"10.1038/s41467-024-51897-3","title":"Direct recognition of an intact foreign protein by an αβ T cell receptor","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute on Aging; Monash Biomedicine Discovery Institute, Monash University; National Health and Medical Research Council; National Institutes of Health; Australian Synchrotron; Medical Research Council; Fundação para a Ciência e a Tecnologia; Australian Nuclear Science and Technology Organisation; Brigham Young University","keywords":"Receptor; Computational biology; Cell biology; Computer science; Chemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006473002,0.0002369753,0.0001766656,0.00009269421,0.00008896742,0.0003420023,0.0001723178,0.0003515189,0.001556223],"category_scores_gemma":[0.00008490596,0.0001173462,0.0001896555,0.00008452321,0.0001405932,0.0002268683,0.0002876617,0.0005853151,0.00101036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539506,"about_ca_system_score_gemma":0.0001156566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001462358,"about_ca_topic_score_gemma":0.0001103083,"domain_scores_codex":[0.9998842,0.0000114813,0.000008109591,0.00003244437,0.00003843898,0.00002530532],"domain_scores_gemma":[0.9999384,0.000009414566,0.00001509923,0.00001313966,0.000008819085,0.00001509229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001384623,0.000006446458,0.0001058442,0.00001287002,0.000001424445,0.0000710027,0.000006763424,0.00002961019,0.9987791,0.0001308438,0.00002995645,0.0008123466],"study_design_scores_gemma":[0.00001204581,0.0001709038,0.001771702,0.0000055463,0.00001270204,0.001316543,0.00002862295,0.001050754,0.9885281,0.0001072868,0.006991521,0.000004270422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795688,0.001697654,0.01331809,0.0001693188,0.00008131479,0.00003037689,0.000154496,0.0001522697,0.004827822],"genre_scores_gemma":[0.984769,0.001273334,0.00738975,0.0001615558,0.00002549121,0.0000243307,0.000305495,0.00002086041,0.0060302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001556223,"threshold_uncertainty_score":0.005206048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631487273415787,"score_gpt":0.2728036920826616,"score_spread":0.2564888193485038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}