{"id":"W4403344343","doi":"10.1016/j.bone.2024.117282","title":"A novel genetic mouse model of osteoporosis with double heterozygosity of Irx3 and Irx5 characterizes sex-dependent phenotypes in bone homeostasis","year":2024,"lang":"en","type":"article","venue":"Bone","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Cyrus Tang Foundation","keywords":"Loss of heterozygosity; Phenotype; Biology; Osteoporosis; Genetics; Allele; Evolutionary biology; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004152956,0.001512323,0.0007429559,0.003045086,0.0005401658,0.0005343563,0.001016604,0.001161035,0.00614771],"category_scores_gemma":[0.0002200686,0.0005700975,0.0007413498,0.0007439468,0.000889228,0.0004798199,0.0006670773,0.001472704,0.001173305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003299438,"about_ca_system_score_gemma":0.0003672172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006391595,"about_ca_topic_score_gemma":0.002276113,"domain_scores_codex":[0.9995233,0.00004227826,0.00006502122,0.0001196365,0.0001730775,0.00007660862],"domain_scores_gemma":[0.9995327,0.00005320651,0.0001966222,0.00004234152,0.00003432703,0.0001407957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001850654,0.00009963365,0.000392044,0.00003226221,0.00001766872,0.0005288766,0.00002743039,0.00004896637,0.9965686,0.0008654386,0.0001288727,0.00110508],"study_design_scores_gemma":[0.0003511291,0.0008926406,0.01470072,0.00006224107,0.0002867875,0.009793423,0.0001848177,0.001938271,0.9588724,0.0008467164,0.01201725,0.00005357401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967377,0.001332369,0.02110856,0.0004706334,0.0001768595,0.0001914842,0.002881751,0.0009536769,0.005507554],"genre_scores_gemma":[0.9401521,0.001630161,0.02279863,0.0004007783,0.00008320915,0.0004653537,0.003471752,0.0004980694,0.03049989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00614771,"threshold_uncertainty_score":0.02056617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01249121149836389,"score_gpt":0.2228269303778891,"score_spread":0.2103357188795252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}