{"id":"W4403350405","doi":"10.1101/2024.10.10.616291","title":"Intranasal hemagglutinin protein boosters induce robust mucosal immunity and cross-protection against influenza A viral challenge","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Hemagglutinin (influenza); Nasal administration; Mucosal immunity; Virology; Immunity; Immunology; Medicine; Immune system; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899995,0.0002383205,0.0002051068,0.0001534377,0.0001747832,0.0002062785,0.0001118752,0.0002595116,0.009122826],"category_scores_gemma":[0.0001943678,0.00007276075,0.000168739,0.00005373141,0.00009924258,0.0001226908,0.0001063978,0.0004205305,0.004353647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001288181,"about_ca_system_score_gemma":0.000243679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001765501,"about_ca_topic_score_gemma":0.0004446283,"domain_scores_codex":[0.9999397,0.000007505885,0.000006823102,0.00001037023,0.00002548918,0.00001009694],"domain_scores_gemma":[0.9999104,0.00001648289,0.00001394399,0.000009847229,0.00002164638,0.00002770794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002801706,0.000122237,0.0002459164,0.000095298,0.000004074433,0.00007709271,0.00001958361,0.00001815288,0.9880634,0.00008737299,0.002182495,0.008804106],"study_design_scores_gemma":[0.0001060226,0.001618037,0.01387194,0.00003241362,0.00002902829,0.0006759689,0.00005096883,0.0004532834,0.9449293,0.0001749361,0.03805036,0.00000763442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501315,0.003768904,0.01114931,0.00235175,0.003019553,0.0004720822,0.002307049,0.001287878,0.02551206],"genre_scores_gemma":[0.8669505,0.002972542,0.01559825,0.0012088,0.001041426,0.0002299709,0.002405029,0.0003561367,0.1092373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009122826,"threshold_uncertainty_score":0.03051889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0658908857144913,"score_gpt":0.3122825290443887,"score_spread":0.2463916433298974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}