{"id":"W4403350861","doi":"10.1101/2024.10.08.617315","title":"Genetic reduction of the translational repressors FMRP and 4E-BP2 preserves memory in mouse models of Alzheimer’s disease","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; McGill University; Université de Montréal","funders":"","keywords":"Repressor; Reduction (mathematics); Disease; Biology; Neuroscience; Genetics; Medicine; Gene; Pathology; Transcription factor; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002458547,0.000706446,0.0004847077,0.0008508243,0.0002462544,0.0004365778,0.0004071438,0.0005786755,0.001851926],"category_scores_gemma":[0.0001294527,0.0002748564,0.0003337554,0.0003084051,0.0004808178,0.0003076081,0.0002601435,0.001075751,0.0006444965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003171294,"about_ca_system_score_gemma":0.0002493927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009650302,"about_ca_topic_score_gemma":0.00115839,"domain_scores_codex":[0.9997928,0.00002477995,0.00002279035,0.00004931692,0.00006030294,0.00005015291],"domain_scores_gemma":[0.9997784,0.00001673818,0.0000817203,0.00003032673,0.00002017179,0.00007256878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002523379,0.00004953242,0.00006826902,0.00001983786,0.0000064669,0.00003378224,0.00001090026,0.0000273991,0.998638,0.000081821,0.00005278153,0.0007589748],"study_design_scores_gemma":[0.00004631915,0.0003294431,0.002018303,0.000008901488,0.00002228538,0.0001218615,0.00002174395,0.0003459426,0.9948697,0.00008975485,0.002119167,0.000006467448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869567,0.00267102,0.005449306,0.0004272572,0.0001664947,0.00004721503,0.001575338,0.0006358857,0.002070675],"genre_scores_gemma":[0.9768586,0.001863866,0.005798357,0.0001828719,0.00005373492,0.0001202851,0.001417805,0.0002502566,0.0134543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001851926,"threshold_uncertainty_score":0.006195307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03307937148712906,"score_gpt":0.2475555900737563,"score_spread":0.2144762185866272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}