{"id":"W4403351897","doi":"10.1016/j.bas.2024.103912","title":"INDIGO: A global, randomized, double-blinded, phase 3 study of vorasidenib versus placebo in patients with residual or recurrent grade 2 glioma with an IDH1/2 mutation","year":2024,"lang":"en","type":"article","venue":"Brain and Spine","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Placebo; Glioma; Double blinded; Indigo; IDH1; Residual; Medicine; Internal medicine; Mutation; Biology; Pathology; Genetics; Cancer research; Mathematics; Physics; Gene; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001145176,0.001895352,0.003223224,0.0006452927,0.0004071842,0.001380138,0.001127988,0.001740852,0.006806368],"category_scores_gemma":[0.001117758,0.0006910382,0.002109011,0.0005206537,0.001394546,0.001248482,0.0004248474,0.003909896,0.001116501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008770416,"about_ca_system_score_gemma":0.001188386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001212761,"about_ca_topic_score_gemma":0.0043181,"domain_scores_codex":[0.9996265,0.000193632,0.00001519107,0.00006436296,0.00002499907,0.00007531283],"domain_scores_gemma":[0.9996276,0.0001050196,0.00008030699,0.0000270131,0.00002504124,0.0001350488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9674763,0.004329266,0.0004872251,0.0009683609,0.001660322,0.00005105539,0.00008082918,0.0005187478,0.003837982,0.0002368341,0.00154934,0.01880365],"study_design_scores_gemma":[0.9685732,0.02819912,0.001107911,0.00003748482,0.0004776537,0.00003935174,0.00003673302,0.000336026,0.0003428114,0.0001716964,0.0006597835,0.00001815739],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769937,0.0103472,0.001100053,0.001461229,0.0007890351,0.002640891,0.001793915,0.0004428294,0.004431147],"genre_scores_gemma":[0.9823143,0.004519438,0.001693245,0.002188856,0.0002917239,0.002718978,0.001498608,0.00006409462,0.004710732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006806368,"threshold_uncertainty_score":0.02276957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03610060696585985,"score_gpt":0.3544073721142696,"score_spread":0.3183067651484097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}