{"id":"W4403356879","doi":"10.1038/s41598-024-75305-4","title":"Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study","year":2024,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Faculty of Medicine and Health, University of Sydney; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; Cancer Council Victoria; National Health and Medical Research Council; Norwegian Institute of Public Health; World Cancer Research Fund; Medical Research Council; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Chonnam National University Hwasun Hospital; Centers for Disease Control and Prevention; Biobanco Vasco; Damon Runyon Cancer Research Foundation; Karl-Franzens-Universität Graz; School of Public Health, Imperial College London; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Xunta de Galicia; University of South Florida; Helse Midt-Norge; Vetenskapsrådet; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; Imperial College London; Generalitat de Catalunya; Canadian Institutes of Health Research; Cancerfonden; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Institut Gustave-Roussy; Medizinische Universität Graz; Grantová Agentura České Republiky; Harvard T.H. Chan School of Public Health; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Institut National de la Santé et de la Recherche Médicale; Marshfield Clinic Research Foundation; Moffitt Cancer Center; Norges Teknisk-Naturvitenskapelige Universitet; Ligue Contre le Cancer; Univerzita Karlova v Praze; Deutsches Krebsforschungszentrum; Mike and Josie Harper Cancer Research Institute; National Institutes of Health; Florida Department of Health; University of Pittsburgh; Memorial Sloan-Kettering Cancer Center; Johns Hopkins University; Brigham and Women's Hospital; World Health Organization; Wageningen University and Research; Cancer Research UK; American Cancer Society; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Sex hormone-binding globulin; Testosterone (patch); Oncology; Colorectal cancer; Hormone; Medicine; Hazard ratio; Internal medicine; Genome-wide association study; Physiology; Confidence interval; Cancer; Bioinformatics; Androgen; Biology; Single-nucleotide polymorphism; Genetics; Genotype; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01090616,0.0005990863,0.001113985,0.0006153167,0.0003444136,0.0005576704,0.0006008341,0.0009058564,0.001712548],"category_scores_gemma":[0.02656217,0.0004385603,0.001459244,0.0009084122,0.0005766521,0.0003441221,0.000356978,0.0004418454,0.0001822458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002971126,"about_ca_system_score_gemma":0.0005263825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002112568,"about_ca_topic_score_gemma":0.001253877,"domain_scores_codex":[0.9860374,0.01071483,0.0006984976,0.001429209,0.000836924,0.0002831141],"domain_scores_gemma":[0.9912639,0.004896108,0.001362101,0.001987205,0.000303776,0.0001868725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06654733,0.001122356,0.845022,0.0006164967,0.01575926,0.002616683,0.0008330194,0.003058489,0.01283621,0.006988994,0.002856888,0.04174238],"study_design_scores_gemma":[0.03085499,0.0254662,0.8060196,0.0003232238,0.02527947,0.01169437,0.0005206716,0.06419268,0.006091905,0.01787434,0.01128862,0.00039389],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772419,0.001670044,0.01834436,0.0003673285,0.0001181899,0.000526869,0.00053228,0.0001070377,0.001091986],"genre_scores_gemma":[0.9938805,0.0001821508,0.00502352,0.0001615123,0.00003538157,0.0002313343,0.0001720589,0.00001748574,0.0002959051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01090616,"threshold_uncertainty_score":0.05767798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005033438716615731,"score_gpt":0.2517845745866042,"score_spread":0.2467511358699885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}