{"id":"W4403378348","doi":"10.1101/2024.10.08.617317","title":"Bio-engineering a common probiotic to exploit colonic inflammation promotes reliable efficacy in translational models of colitis","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia, Okanagan Campus; Kelowna General Hospital; University of British Columbia","funders":"","keywords":"Colitis; Probiotic; Inflammation; Immune system; Microbiome; Immunology; Inflammatory bowel disease; Disease; Medicine; Ulcerative colitis; Biology; Bacteria; Bioinformatics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004368838,0.000478032,0.0004663155,0.00031246,0.000149595,0.0003799405,0.0002035277,0.0005004477,0.001156642],"category_scores_gemma":[0.0001798729,0.0001473827,0.0004075982,0.0001860596,0.0003575733,0.0002859263,0.0002920542,0.001060586,0.0002224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001763468,"about_ca_system_score_gemma":0.0002622243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002089921,"about_ca_topic_score_gemma":0.000404071,"domain_scores_codex":[0.9996867,0.00005553443,0.00003716545,0.00005632796,0.0001021979,0.0000619717],"domain_scores_gemma":[0.9997875,0.00002613424,0.00007833991,0.00002537147,0.00003244398,0.00005029385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002713367,0.0001534587,0.00007534964,0.00008863771,0.000007888185,0.00001630411,0.000007830009,0.0001141706,0.9975488,0.00007363358,0.0000325674,0.001610123],"study_design_scores_gemma":[0.00005571781,0.004368621,0.001173663,0.00001937901,0.00003167698,0.0000725808,0.00002482907,0.0007339449,0.9912081,0.00007056239,0.002233109,0.000007791689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821382,0.002239413,0.01275189,0.0002959149,0.0001790693,0.0001759548,0.0004188502,0.0001914844,0.00160926],"genre_scores_gemma":[0.9863213,0.001203949,0.00961799,0.0001328349,0.00002548629,0.0001830165,0.0004102531,0.00003563589,0.002069519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001156642,"threshold_uncertainty_score":0.003869295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01223187598817731,"score_gpt":0.2267774926784552,"score_spread":0.2145456166902779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}