{"id":"W4403381392","doi":"10.1016/j.stem.2024.09.011","title":"Embryonic macrophages support endocrine commitment during human pancreatic differentiation","year":2024,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; University of Toronto; Toronto General Hospital; Toronto Rehabilitation Institute; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Ontario Institute for Regenerative Medicine; Juvenile Diabetes Research Foundation United States of America; R. Howard Webster Foundation; Breakthrough T1D Canada; Toronto General and Western Hospital Foundation","keywords":"Biology; Embryonic stem cell; Endocrine system; Cell biology; Enteroendocrine cell; Endocrinology; Immunology; Genetics; Hormone; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00009149874,0.0002358253,0.0003577246,0.0001591448,0.0001362393,0.00008000589,0.00007390251,0.00006280058,0.002478755],"category_scores_gemma":[0.000003114919,0.0001960431,0.0001611167,0.0001697261,0.00003452556,0.00007229154,0.00005222271,0.0001915693,0.001090731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001703574,"about_ca_system_score_gemma":0.00005248913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000142439,"about_ca_topic_score_gemma":0.000001081473,"domain_scores_codex":[0.9986351,0.00004718985,0.0003148459,0.0003682869,0.0002749262,0.0003596906],"domain_scores_gemma":[0.9992775,0.00007631527,0.00006064729,0.0003591886,0.00003604486,0.0001902594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005776406,0.0004364896,0.01864226,0.004696963,0.0001483657,0.0004171822,0.0004671667,0.000008012954,0.9649373,0.0001673837,0.009006917,0.001014164],"study_design_scores_gemma":[0.002628413,0.0004916264,0.03491483,0.0002985998,0.0006555331,0.00005109112,0.0003599959,0.0004951063,0.9451011,0.00004319812,0.01465282,0.0003076962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9386728,0.003124248,0.00004938837,0.0001411564,0.0005014337,0.0004179136,0.00001119461,0.0003041268,0.05677769],"genre_scores_gemma":[0.8565731,0.0001637815,0.00004400844,0.00009145022,0.0001959529,0.00005121707,0.0001174169,0.0000419124,0.1427211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08594345,"threshold_uncertainty_score":0.999687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01276801720382034,"score_gpt":0.2450802893951245,"score_spread":0.2323122721913042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}