{"id":"W4403381392","doi":"10.1016/j.stem.2024.09.011","title":"Embryonic macrophages support endocrine commitment during human pancreatic differentiation","year":2024,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; University of Toronto; Toronto General Hospital; Toronto Rehabilitation Institute; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Ontario Institute for Regenerative Medicine; Juvenile Diabetes Research Foundation United States of America; R. Howard Webster Foundation; Breakthrough T1D Canada; Toronto General and Western Hospital Foundation","keywords":"Biology; Embryonic stem cell; Endocrine system; Cell biology; Enteroendocrine cell; Endocrinology; Immunology; Genetics; Hormone; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000611402,0.0002413287,0.0002799685,0.0003403971,0.0002007829,0.0005843109,0.0002023944,0.0002646059,0.002269643],"category_scores_gemma":[0.0003846933,0.0001976245,0.0002787898,0.0001491536,0.0002268134,0.0002641845,0.0006688254,0.0008746535,0.0008014769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001747185,"about_ca_system_score_gemma":0.0002430201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003856049,"about_ca_topic_score_gemma":0.0009196877,"domain_scores_codex":[0.9996569,0.00011287,0.00003546165,0.0000389219,0.00005296741,0.0001028242],"domain_scores_gemma":[0.9995778,0.0001839767,0.00004251759,0.00007832124,0.00005300243,0.0000643543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001918351,0.0001107455,0.002828586,0.00007361585,0.00001572693,0.0004465368,0.0002452037,0.0001031657,0.9866498,0.0009806571,0.0003630939,0.006264441],"study_design_scores_gemma":[0.0001450604,0.0005349123,0.01917605,0.00006214363,0.00006043823,0.0006087028,0.0004196128,0.000531251,0.9561521,0.0003130509,0.02198712,0.000009632427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859276,0.003244886,0.003460883,0.0002333168,0.0001074515,0.00005403415,0.0004690827,0.0000728928,0.00642991],"genre_scores_gemma":[0.990001,0.0008601624,0.001570832,0.0001666696,0.00004150683,0.0000548944,0.0005530439,0.0000533911,0.006698489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002269643,"threshold_uncertainty_score":0.007592738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01276801720382034,"score_gpt":0.2450802893951245,"score_spread":0.2323122721913042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}