{"id":"W4403400294","doi":"10.3390/cancers16203454","title":"From Deworming to Cancer Therapy: Benzimidazoles in Hematological Malignancies","year":2024,"lang":"en","type":"review","venue":"Cancers","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Penn State Hershey Cancer Institute; National Institutes of Health; Pennsylvania State University; National Cancer Institute; University of Pennsylvania","keywords":"Drug repositioning; Repurposing; Medicine; Drug; Deworming; Pharmacology; Cancer; Oncology; Cancer research; Bioinformatics; Biology; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002919098,0.0006470815,0.000883683,0.001653792,0.0002327168,0.0006515865,0.0007352648,0.0008779061,0.004018064],"category_scores_gemma":[0.000420147,0.0001957667,0.0005167486,0.001291175,0.0003759477,0.001077777,0.0004923299,0.002151096,0.001751079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004788901,"about_ca_system_score_gemma":0.0005403063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000806132,"about_ca_topic_score_gemma":0.002082458,"domain_scores_codex":[0.9998785,0.0000201165,0.00001500451,0.00002107383,0.00005145563,0.0000137672],"domain_scores_gemma":[0.999866,0.00005958583,0.00002071595,0.000004222426,0.00003272953,0.00001669663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008267489,0.00007697047,0.0001226788,0.01204804,0.00007620691,0.0002377328,0.00005573391,0.0003070383,0.002236094,0.002749303,0.03971314,0.9422944],"study_design_scores_gemma":[0.00002991863,0.000141628,0.0006417566,0.00260489,0.00007949182,0.001408547,0.00004060084,0.00009204388,0.0005752978,0.001627522,0.9927453,0.00001285643],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001783866,0.9978593,0.0001450805,0.0003536151,0.0003142963,0.000005555678,0.00001426504,0.0000134516,0.001116017],"genre_scores_gemma":[0.000944696,0.9970037,0.0001841042,0.000419441,0.0002616806,0.000006729584,0.00003107031,0.000002285851,0.001146267],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004018064,"threshold_uncertainty_score":0.0134418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06292998033394977,"score_gpt":0.3960345325005239,"score_spread":0.3331045521665741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}