{"id":"W4403402828","doi":"10.3390/ph17101366","title":"Evaluation of Safety and Efficacy of Cell Therapy Based on Osteoblasts Derived from Umbilical Cord Mesenchymal Stem Cells for Osteonecrosis of the Femoral Head: Study Protocol for a Single-Center, Open-Label, Phase I Clinical Trial","year":2024,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Bone and Joint Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of SMEs and Startups","keywords":"Medicine; Mesenchymal stem cell; Umbilical cord; Femoral head; Stem cell; Single Center; Open label; Surgery; Pathology; Anatomy; Biology; Randomized controlled trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003178341,0.000242962,0.0009348308,0.00007175755,0.00006343485,0.00003733083,0.000207495,0.000111884,0.0001139555],"category_scores_gemma":[0.0004633103,0.0001599621,0.0003109668,0.0001969332,0.0002374981,0.00007311654,0.00009939704,0.0001829108,0.000001104768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005555473,"about_ca_system_score_gemma":0.0005751756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001623546,"about_ca_topic_score_gemma":0.00000632515,"domain_scores_codex":[0.996028,0.00100917,0.001389653,0.0005359365,0.0007924175,0.0002448012],"domain_scores_gemma":[0.9951496,0.003422491,0.0003381709,0.0004234962,0.0004588224,0.0002074145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.555889,0.05832873,0.0007599697,0.0006344784,0.0003529809,0.00000200284,0.0002237148,0.000005437847,0.2573027,0.000005233675,0.0002329714,0.1262628],"study_design_scores_gemma":[0.5533224,0.03340101,0.0006481103,0.0005779926,0.001620624,7.292399e-7,0.0001149328,0.02575858,0.383411,0.00002886372,0.0009742973,0.000141526],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7505673,0.00005150607,0.0001621353,0.0003286936,0.0002115242,0.2480876,0.0005257025,0.00001687998,0.00004861719],"genre_scores_gemma":[0.9537564,0.000005430066,0.0004839305,0.000248848,0.00009337568,0.04533879,0.00002099912,0.00003810117,0.00001414485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2031891,"threshold_uncertainty_score":0.6523066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5110963683343537,"score_gpt":0.5700362030566508,"score_spread":0.05893983472229714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}