{"id":"W4403402828","doi":"10.3390/ph17101366","title":"Evaluation of Safety and Efficacy of Cell Therapy Based on Osteoblasts Derived from Umbilical Cord Mesenchymal Stem Cells for Osteonecrosis of the Femoral Head: Study Protocol for a Single-Center, Open-Label, Phase I Clinical Trial","year":2024,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Bone and Joint Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of SMEs and Startups","keywords":"Medicine; Mesenchymal stem cell; Umbilical cord; Femoral head; Stem cell; Single Center; Open label; Surgery; Pathology; Anatomy; Biology; Randomized controlled trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0100328,0.004221996,0.005484713,0.00118633,0.001668213,0.001901431,0.002795778,0.004291832,0.0142556],"category_scores_gemma":[0.006229178,0.001388422,0.001971269,0.00118328,0.002554279,0.001712895,0.000840223,0.004869284,0.003405144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001778867,"about_ca_system_score_gemma":0.008213464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006669273,"about_ca_topic_score_gemma":0.001585376,"domain_scores_codex":[0.995683,0.002286579,0.0003837573,0.0004632667,0.0005897697,0.0005936981],"domain_scores_gemma":[0.9961046,0.0006571689,0.0009040622,0.0006147749,0.0006326492,0.001086809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8320223,0.1047677,0.0009397794,0.002843286,0.0005656102,0.0002173215,0.0002396353,0.002171869,0.02286341,0.0009678195,0.005229895,0.02717133],"study_design_scores_gemma":[0.6955059,0.2872189,0.002209197,0.0002682891,0.000310474,0.00009513929,0.00006662981,0.00113547,0.003545223,0.0005908401,0.009000025,0.00005385801],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1549713,0.001452483,0.006062964,0.0006215925,0.0006166749,0.828427,0.003462142,0.0003056194,0.004080258],"genre_scores_gemma":[0.1123453,0.001576824,0.008998138,0.001365758,0.0003774088,0.8697607,0.002214595,0.00005005362,0.003311313],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0142556,"threshold_uncertainty_score":0.05305916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5110963683343537,"score_gpt":0.5700362030566508,"score_spread":0.05893983472229714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}