{"id":"W4403410124","doi":"10.1016/j.jtho.2024.09.632","title":"P3.12D.10 Phase 1b Study of AMG 193, An MTA-Cooperative PRMT5i, Alone and in Combination with Other Therapies in MTAP-deleted NSCLC","year":2024,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Oncology; Phase (matter); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001545412,0.001990949,0.002441523,0.0008417259,0.0006003561,0.00163266,0.001383612,0.001779876,0.005031722],"category_scores_gemma":[0.000588224,0.0007923772,0.001761777,0.0006245185,0.001281793,0.0008143539,0.0004168603,0.004245639,0.00150046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001605449,"about_ca_system_score_gemma":0.002545177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004802046,"about_ca_topic_score_gemma":0.008238954,"domain_scores_codex":[0.9995134,0.0001600825,0.00001751254,0.00008871222,0.0000506012,0.0001696221],"domain_scores_gemma":[0.9995995,0.00005221375,0.00004285404,0.00004079742,0.00002671442,0.0002378518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4714539,0.1436825,0.005487119,0.001409506,0.002055988,0.0005681053,0.0007138264,0.009381361,0.1860389,0.001233954,0.01664728,0.1613276],"study_design_scores_gemma":[0.3153216,0.6463941,0.01040194,0.00006435534,0.0007842041,0.0004453636,0.0001532457,0.002176338,0.01697337,0.0004336498,0.006789738,0.00006213311],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856586,0.003013942,0.0008326707,0.001024294,0.0002655259,0.002050478,0.003389966,0.0002636632,0.003500897],"genre_scores_gemma":[0.9763155,0.003166121,0.00232907,0.00115944,0.0001782808,0.002857683,0.00601934,0.0001219163,0.007852649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005031722,"threshold_uncertainty_score":0.01683283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01572690049500855,"score_gpt":0.38711162080502,"score_spread":0.3713847203100115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}