{"id":"W4403411478","doi":"10.1016/j.arr.2024.102546","title":"Epigenetic clocks and programmatic aging","year":2024,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Wellcome Trust","keywords":"Epigenetics; Neuroscience; Biology; Computational biology; Cognitive science; Psychology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004527281,0.0005103397,0.001940729,0.0007072058,0.0003493055,0.0006648646,0.0006257278,0.0002373665,0.00006325867],"category_scores_gemma":[0.003566359,0.0003461775,0.000528704,0.00190275,0.000369554,0.000104887,0.0005998858,0.002159069,0.004484996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001568649,"about_ca_system_score_gemma":0.0003215726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001089126,"about_ca_topic_score_gemma":0.000004804046,"domain_scores_codex":[0.9935023,0.002424602,0.001006204,0.001265441,0.0007052469,0.001096195],"domain_scores_gemma":[0.9972676,0.001189241,0.0001952898,0.0009215915,0.00003513177,0.000391138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[1.583459e-7,0.000010899,3.544858e-7,0.08326832,0.000008504232,0.0006992443,0.00009547528,8.122473e-9,0.000008290241,0.001491737,0.001785183,0.9126318],"study_design_scores_gemma":[0.00003294909,0.00003698801,4.795133e-7,0.07364687,0.0002335689,0.0003092562,0.000004263784,0.000008881829,0.00001702608,0.0002895111,0.925124,0.0002961885],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000008640891,0.9928329,0.000008960831,0.00007683699,0.0003828524,0.003961829,0.000008054396,0.000109177,0.002610739],"genre_scores_gemma":[0.00001254151,0.9898367,0.0001186194,0.00003957751,0.0004054907,0.001157951,0.000005890152,0.0001226999,0.008300545],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9233388,"threshold_uncertainty_score":0.999899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3554948150510435,"score_gpt":0.4952439797418751,"score_spread":0.1397491646908316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}