{"id":"W4403417084","doi":"10.1021/acs.analchem.4c02929","title":"Direct <i>Klebsiella pneumoniae</i> Carbapenem Resistance and Carbapenemases Genotype Prediction by Al-MOF/TiO<sub>2</sub>@Au Cubic Heterostructures-Assisted Intact Bacterial Cells Metabolic Analysis","year":2024,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"Natural Science Foundation of Zhejiang Province; National Key Research and Development Program of China","keywords":"Klebsiella pneumoniae; Chemistry; Genotype; Microbiology; Carbapenem; Heterojunction; Gene; Antibiotics; Optoelectronics; Escherichia coli; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152845,0.0002956703,0.0001956006,0.0003222343,0.0001278722,0.0002923654,0.0001826168,0.0004490324,0.0004140678],"category_scores_gemma":[0.0003657964,0.0001619337,0.0002038788,0.0001807339,0.0001947255,0.0002256497,0.0002388911,0.0002808775,0.0001867608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002137609,"about_ca_system_score_gemma":0.0002143322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001609983,"about_ca_topic_score_gemma":0.003161075,"domain_scores_codex":[0.9998652,0.0000129324,0.000007538971,0.00004936868,0.00004668733,0.00001824681],"domain_scores_gemma":[0.9998645,0.00003221907,0.00003945738,0.00001219372,0.00004131609,0.00001024738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005016003,0.000009647134,0.001325179,0.00003956615,0.000007541566,0.00003156565,0.00001403477,0.0003343546,0.9910401,0.00002462068,0.00007194356,0.007051216],"study_design_scores_gemma":[0.000004481458,0.00008492726,0.006269025,0.000004698377,0.00001284359,0.0001541348,0.00003338785,0.01371692,0.9789549,0.0000544889,0.000689527,0.00002061356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454057,0.001159508,0.050568,0.0001599583,0.00003519473,0.00005431181,0.0005737226,0.0005945503,0.001449077],"genre_scores_gemma":[0.9477369,0.0005172841,0.05004498,0.0001156698,0.00001187071,0.00004339295,0.000294482,0.0000349914,0.001200448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001609983,"threshold_uncertainty_score":0.003201246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004557631711734061,"score_gpt":0.2170742632302712,"score_spread":0.2125166315185371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}