{"id":"W4403420370","doi":"10.1016/j.jtho.2024.09.633","title":"P3.12D.11 Phase 1/2, Dose-expansion Study of AMG 193, an MTA-cooperative PRMT5 Inhibitor, In MTAP-deleted NSCLC","year":2024,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Protein arginine methyltransferase 5; Pharmacology; Maximum tolerated dose; Phase (matter); Oncology; Internal medicine; Adverse effect; Methyltransferase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001435255,0.001699456,0.002273394,0.0008561307,0.0006368774,0.001434239,0.001384328,0.001727435,0.003342583],"category_scores_gemma":[0.00058738,0.0007417907,0.001249326,0.0005511252,0.001122432,0.0007947823,0.0003476224,0.004041234,0.00110964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001576908,"about_ca_system_score_gemma":0.002236718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004213653,"about_ca_topic_score_gemma":0.008178161,"domain_scores_codex":[0.9995566,0.0001458969,0.00001615667,0.00007869054,0.0000554446,0.000147144],"domain_scores_gemma":[0.9996504,0.00005549202,0.00003993031,0.00003817684,0.00002755088,0.000188576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3196167,0.1535569,0.007264121,0.001458889,0.001543031,0.000791164,0.0008364123,0.014736,0.2854011,0.001591652,0.01805919,0.1951448],"study_design_scores_gemma":[0.3163802,0.6150383,0.01578657,0.00008168331,0.0008440045,0.0006885924,0.0001963505,0.004650141,0.03510092,0.0006613905,0.0104792,0.00009262493],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871967,0.00256672,0.001005697,0.0008851396,0.0001782048,0.002173359,0.002250995,0.0002542096,0.003489066],"genre_scores_gemma":[0.9784213,0.002538399,0.002982116,0.00122448,0.0001533877,0.0026913,0.004287409,0.0001226476,0.007578986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004213653,"threshold_uncertainty_score":0.01144129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02022742145511315,"score_gpt":0.4159568525205271,"score_spread":0.3957294310654139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}