{"id":"W4403420954","doi":"10.1371/journal.pone.0311655","title":"The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Departament de Salut, Generalitat de Catalunya; Université Lille 1 - Sciences et Technologies; Université Claude Bernard Lyon 1; Centre National de la Recherche Scientifique; Generalitat de Catalunya; Centres de Recerca de Catalunya; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Ministerio de Ciencia, Innovación y Universidades; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"HBx; cccDNA; Biology; RNA polymerase II; Transcription (linguistics); Hepatitis B virus; RNA; Chromatin; Enhancer; Virology; Gene; Transcription factor; Kinase; Promoter; Molecular biology; Cell biology; Virus; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544442,0.000487374,0.0004064925,0.0002946733,0.000249849,0.000385098,0.000223894,0.0002812205,0.001264618],"category_scores_gemma":[0.000134936,0.000220117,0.0003286316,0.0001466563,0.0002666932,0.0002968968,0.0003326049,0.0005016123,0.0007237839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005045062,"about_ca_system_score_gemma":0.0002051794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002486325,"about_ca_topic_score_gemma":0.0004457949,"domain_scores_codex":[0.9998237,0.00002855144,0.00001510622,0.00005834528,0.00003648307,0.00003773509],"domain_scores_gemma":[0.9999186,0.00000894645,0.00003759584,0.000007285173,0.000008440968,0.00001922956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001435175,0.00002240411,0.0005553224,0.0001212734,0.00001411756,0.00007499319,0.00001081657,0.0001542822,0.9951391,0.0001759505,0.0001030587,0.003485057],"study_design_scores_gemma":[0.00003751787,0.0003022494,0.007214954,0.0000122546,0.00003889709,0.001266933,0.000031226,0.001792746,0.9816554,0.0001064552,0.007527961,0.0000133719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716846,0.01832101,0.005070814,0.0002627371,0.00007013132,0.00004700829,0.0005035279,0.0001473108,0.003892788],"genre_scores_gemma":[0.9913765,0.003251884,0.00184285,0.00005638218,0.00001412048,0.00003383752,0.0003603049,0.0000189573,0.003045119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001264618,"threshold_uncertainty_score":0.004230618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02917684352907664,"score_gpt":0.2363618676125702,"score_spread":0.2071850240834935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}