{"id":"W4403422944","doi":"10.1093/cei/uxae090","title":"Intrinsic functional defects in B cells of patients with <i>NFKB2</i> mutations","year":2024,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"China Postdoctoral Science Foundation; Fudan University; National Natural Science Foundation of China","keywords":"Hypogammaglobulinemia; Common variable immunodeficiency; Missense mutation; Immunoglobulin D; Frameshift mutation; Immunoglobulin class switching; B cell; Mutation; Biology; Peripheral blood mononuclear cell; Immunology; Molecular biology; Genetics; Antibody; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001708721,0.0006455683,0.0002527599,0.0008932596,0.0004775153,0.0004513562,0.0002296834,0.0004454432,0.001468078],"category_scores_gemma":[0.000609979,0.0002264318,0.0002592376,0.0003603574,0.00032191,0.0002197844,0.0003248865,0.0003415652,0.0003388468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001712585,"about_ca_system_score_gemma":0.00009892361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001250279,"about_ca_topic_score_gemma":0.0006498676,"domain_scores_codex":[0.9998053,0.00002780094,0.00002472884,0.00005695599,0.00004416842,0.00004108172],"domain_scores_gemma":[0.9997779,0.0000411254,0.00006633414,0.00001625137,0.00003018176,0.00006819439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001501088,0.0001772071,0.5763436,0.0001649565,0.0002134861,0.04291885,0.002183931,0.0004398505,0.3516797,0.000353116,0.0005526422,0.02347151],"study_design_scores_gemma":[0.00008954085,0.0006937434,0.8015423,0.00004554684,0.0001613595,0.1618421,0.0005979678,0.0004817134,0.03133708,0.0002050029,0.002978657,0.00002501492],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988737,0.0002505259,0.0001998718,0.00001544232,0.000002993317,0.000005511483,0.00009935039,0.00001888703,0.0005337521],"genre_scores_gemma":[0.9994935,0.00009059047,0.0001353788,0.00001712245,0.000004740186,0.000003916296,0.0001434911,0.000006299034,0.0001049044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001468078,"threshold_uncertainty_score":0.004911244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01769504550557477,"score_gpt":0.2977259949358806,"score_spread":0.2800309494303058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}