{"id":"W4403422944","doi":"10.1093/cei/uxae090","title":"Intrinsic functional defects in B cells of patients with <i>NFKB2</i> mutations","year":2024,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"China Postdoctoral Science Foundation; Fudan University; National Natural Science Foundation of China","keywords":"Hypogammaglobulinemia; Common variable immunodeficiency; Missense mutation; Immunoglobulin D; Frameshift mutation; Immunoglobulin class switching; B cell; Mutation; Biology; Peripheral blood mononuclear cell; Immunology; Molecular biology; Genetics; Antibody; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363139,0.0001351548,0.0002030784,0.00006759715,0.00002722029,0.00001008438,0.0001212626,0.0001934197,0.00009148755],"category_scores_gemma":[0.00005072865,0.0001197576,0.0001076363,0.0001304651,0.0003574872,0.000006325985,0.000118942,0.0001873356,0.00005616156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000248185,"about_ca_system_score_gemma":0.0001058025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001006829,"about_ca_topic_score_gemma":0.000007084744,"domain_scores_codex":[0.9987965,0.0001155078,0.0004253822,0.0003810145,0.00009280813,0.0001888217],"domain_scores_gemma":[0.9995075,0.00009411427,0.00006925037,0.0002314857,0.00005837507,0.00003930322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000494648,0.0008489192,0.02297372,0.00001219304,0.0001346676,0.0000117745,0.00007155452,0.00003901436,0.9735987,0.0003687174,0.0004789124,0.0009672395],"study_design_scores_gemma":[0.001697507,0.001982361,0.04209699,0.00003759304,0.00001809424,0.000004251868,0.0001016292,0.000009483941,0.9498143,0.00007029089,0.003992933,0.0001745831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961115,0.002336306,0.0001728869,0.00002328014,0.0007949703,0.0001835755,0.00002710517,0.00001877751,0.0003316017],"genre_scores_gemma":[0.9990648,0.00003315342,0.0002815863,0.0001331693,0.00008696771,0.00003642915,0.0002546707,0.00002389598,0.00008532613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02378436,"threshold_uncertainty_score":0.4883572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01769504550557477,"score_gpt":0.2977259949358806,"score_spread":0.2800309494303058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}