{"id":"W4403445836","doi":"10.1101/gad.352108.124","title":"Notch induces transcription by stimulating release of paused RNA polymerase II","year":2024,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; National Cancer Institute; National Science Foundation; National Institutes of Health; Harvard University","keywords":"Chromatin; Biology; Notch signaling pathway; RNA polymerase II; Cell biology; Transcription (linguistics); Transcription factories; Chromatin remodeling; Effector; Transcription factor; Gene expression; Genetics; Gene; Signal transduction; Transcriptional regulation; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001748334,0.0001172125,0.0001026151,0.00005418673,0.0001093365,0.00002430334,0.0001078048,0.00007902076,0.00003048878],"category_scores_gemma":[0.00001859906,0.0001061187,0.00004617878,0.0001065349,0.00002567959,0.000005182742,0.00005931512,0.00006673689,0.000006947352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002039868,"about_ca_system_score_gemma":0.0002119183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000413923,"about_ca_topic_score_gemma":0.00001425,"domain_scores_codex":[0.999043,0.00002868128,0.0002350618,0.0002674574,0.0001935251,0.0002322209],"domain_scores_gemma":[0.9997,0.000008131222,0.00002757622,0.0001324188,0.00004327859,0.00008859902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003403224,0.0000289942,0.00005001136,0.00005305799,0.00005695129,0.000004506249,0.0002050012,0.00003192092,0.874491,0.000008104562,0.0008014161,0.124235],"study_design_scores_gemma":[0.0002123209,0.0001139148,0.0002878619,0.00005027626,0.000007297636,0.000002693916,0.00006943906,0.0001901568,0.9796723,0.000005628802,0.01925913,0.0001290052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904139,0.007333015,0.001701972,0.0001699824,0.0001058915,0.0001181733,0.00001230563,0.00001711325,0.0001276387],"genre_scores_gemma":[0.9962266,0.0003477428,0.001366844,0.00006601943,0.00006804323,0.00002084672,0.0001509572,0.00001802746,0.001734907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.124106,"threshold_uncertainty_score":0.4327397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0149865032397758,"score_gpt":0.2698684348747061,"score_spread":0.2548819316349303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}