{"id":"W4403445836","doi":"10.1101/gad.352108.124","title":"Notch induces transcription by stimulating release of paused RNA polymerase II","year":2024,"lang":"en","type":"article","venue":"Genes & Development","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; National Cancer Institute; National Science Foundation; National Institutes of Health; Harvard University","keywords":"Chromatin; Biology; Notch signaling pathway; RNA polymerase II; Cell biology; Transcription (linguistics); Transcription factories; Chromatin remodeling; Effector; Transcription factor; Gene expression; Genetics; Gene; Signal transduction; Transcriptional regulation; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001202134,0.0001779549,0.0001722658,0.0002090206,0.00009190971,0.0003971648,0.0001074275,0.0001041995,0.0007863797],"category_scores_gemma":[0.0001253715,0.0001597688,0.0002124573,0.00009227161,0.0002105803,0.000130705,0.0001987322,0.0002910727,0.0002942134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000326906,"about_ca_system_score_gemma":0.0001190397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003054561,"about_ca_topic_score_gemma":0.0007528526,"domain_scores_codex":[0.9998748,0.000013305,0.00001013628,0.00004280661,0.00003920299,0.00001974198],"domain_scores_gemma":[0.9999008,0.00002438156,0.00002684928,0.0000127038,0.00001100895,0.00002428915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003120024,0.000003334309,0.0002919483,0.000008935055,0.000002252213,0.00002298423,0.000007327157,0.00002556129,0.9989308,0.00006133315,0.000009391117,0.0006049473],"study_design_scores_gemma":[0.000005368662,0.00007161214,0.008244242,0.000004925876,0.000005481885,0.0001220469,0.00002337699,0.0006892471,0.9896719,0.00008715493,0.001071631,0.000002971798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921067,0.001570772,0.004610434,0.00004291233,0.00002121162,0.00001167959,0.0002631869,0.0000826891,0.001290555],"genre_scores_gemma":[0.9954046,0.0006956983,0.002250286,0.00002805373,0.00001393852,0.00001042335,0.0004253167,0.00001703979,0.00115472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007863797,"threshold_uncertainty_score":0.00263077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0149865032397758,"score_gpt":0.2698684348747061,"score_spread":0.2548819316349303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}