{"id":"W4403450341","doi":"10.1016/j.euroneuro.2024.08.171","title":"57. GENETICS MEETS TRANSCRIPTOMICS: EXPRESSION AND SPLICING OUTLIER ANALYSIS IN WHOLE TRANSCRIPTOMES OF INDIVIDUALS WITH SCHIZOPHRENIA","year":2024,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child, Adolescent and Family Mental Health","funders":"","keywords":"Transcriptome; Computational biology; RNA splicing; Schizophrenia (object-oriented programming); Biology; Genetics; Expression (computer science); Evolutionary biology; Gene expression; Computer science; Psychology; Gene; Psychiatry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007350067,0.0001695483,0.0003888132,0.0004402649,0.000368632,0.0006472295,0.0001336557,0.0003829362,0.001226691],"category_scores_gemma":[0.0009909247,0.0001203794,0.0003904849,0.0005843132,0.000264584,0.0002513159,0.0003665827,0.0003826044,0.0002531858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002043025,"about_ca_system_score_gemma":0.0002873818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001246203,"about_ca_topic_score_gemma":0.003027992,"domain_scores_codex":[0.9997463,0.00004065701,0.00001972629,0.00007336584,0.00006315128,0.00005672501],"domain_scores_gemma":[0.9996909,0.0001141406,0.00007117129,0.00003067222,0.00004626772,0.00004688231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009421788,0.00004078903,0.2607714,0.0001677644,0.0002524383,0.001246026,0.0007500157,0.0009346399,0.6649746,0.001324707,0.00197412,0.06662145],"study_design_scores_gemma":[0.00002700129,0.0001763661,0.9285375,0.00003986146,0.0002577655,0.001745933,0.0006748379,0.003754283,0.05859272,0.002570851,0.003579448,0.00004325312],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905867,0.0008573176,0.005598311,0.0005126371,0.000071442,0.000007464945,0.001325547,0.00008805788,0.0009526182],"genre_scores_gemma":[0.9913202,0.0005786803,0.005856125,0.0003387035,0.00006215513,0.00002013409,0.0009310463,0.00007537222,0.0008176651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001246203,"threshold_uncertainty_score":0.00410372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069127898969098,"score_gpt":0.2830946247267724,"score_spread":0.2724033457370814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}