{"id":"W4403450509","doi":"10.1016/j.euroneuro.2024.08.193","title":"79. DECIPHERING THE GENETIC ARCHITECTURE OF TOURETTE SYNDROME: A LARGE-SCALE GWAS REVEALS NOVEL RISK LOCI AND HIGHLIGHTS BRAIN REGION SPECIFICITY","year":2024,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Genome-wide association study; Genetic architecture; Tourette syndrome; Genetics; Biology; Neuroscience; Medicine; Psychiatry; Quantitative trait locus; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006169961,0.0005154082,0.000530308,0.0002979654,0.0002351621,0.0000826627,0.0008107672,0.000122923,0.0005840728],"category_scores_gemma":[0.00008106646,0.0004071091,0.0002356462,0.0007589548,0.0005506197,0.00007302153,0.0002995268,0.001232395,0.0002491512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003688565,"about_ca_system_score_gemma":0.00002581799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000226934,"about_ca_topic_score_gemma":0.00002334526,"domain_scores_codex":[0.9946208,0.002280361,0.0007440767,0.001261804,0.0002753185,0.0008176664],"domain_scores_gemma":[0.9977098,0.0008370843,0.0003554264,0.000825603,0.00006087511,0.0002112296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002729345,0.002386915,0.0178774,0.0006982589,0.002544006,0.02284425,0.03198872,0.002667329,0.5515928,0.007274697,0.2952534,0.06214283],"study_design_scores_gemma":[0.003570527,0.0007987269,0.811501,0.0001022264,0.0003307103,0.003261448,0.000296626,0.0003695431,0.0001908726,0.0007594663,0.1781591,0.0006597664],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689086,0.003499877,0.007552406,0.006904274,0.00351748,0.0008278526,0.00007900411,0.0004067464,0.008303732],"genre_scores_gemma":[0.9941173,0.0004535046,0.0004524913,0.00251282,0.0006190644,0.00002716683,0.000006619569,0.0002724944,0.001538503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7936236,"threshold_uncertainty_score":0.9998381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135279778780833,"score_gpt":0.2764967631056776,"score_spread":0.2651439653178693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}