{"id":"W4403452413","doi":"10.1167/iovs.65.12.21","title":"A First-Passage Model of Intravitreal Drug Delivery and Residence Time—Influence of Ocular Geometry, Individual Variability, and Injection Location","year":2024,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Engineering and Physical Sciences Research Council; AstraZeneca","keywords":"Residence time (fluid dynamics); Residence; Drug delivery; Medicine; Residence time distribution; Geometry; Ophthalmology; Optometry; Geology; Mathematics; Materials science; Nanotechnology; Demography; Geotechnical engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004822295,0.0008601615,0.0006879682,0.000500739,0.0002920445,0.0009257279,0.001137372,0.001776213,0.001195165],"category_scores_gemma":[0.001197042,0.0003834714,0.001462051,0.0004280309,0.000577306,0.000500719,0.0004129739,0.0006412578,0.0003473077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001470204,"about_ca_system_score_gemma":0.001235601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01832727,"about_ca_topic_score_gemma":0.004536844,"domain_scores_codex":[0.9997682,0.00005183677,0.00001288739,0.00007688219,0.00005422555,0.00003604396],"domain_scores_gemma":[0.9994579,0.0002386824,0.0001469581,0.0000355812,0.00009355643,0.00002744786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001141899,0.00007480015,0.001570727,0.0001117405,0.00003745224,0.0003985803,0.00009812043,0.9662226,0.02371522,0.004118394,0.0003047473,0.003233423],"study_design_scores_gemma":[0.00001334333,0.00004976645,0.0005978547,0.000005971823,0.00002303501,0.00006682472,0.00001057223,0.9969237,0.001530999,0.000389194,0.0003785277,0.00001023551],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5041019,0.00244245,0.4726026,0.001060316,0.0001253012,0.000354461,0.001798329,0.0004941204,0.01702045],"genre_scores_gemma":[0.9602869,0.001132547,0.02590793,0.0001254998,0.00002622207,0.0004456091,0.0004224077,0.00006813473,0.0115848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01832727,"threshold_uncertainty_score":0.03644121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02371277392321243,"score_gpt":0.318064995849336,"score_spread":0.2943522219261236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}