{"id":"W4403453927","doi":"10.1038/s41419-024-07133-3","title":"Loss of miR-200c-3p promotes resistance to radiation therapy via the DNA repair pathway in prostate cancer","year":2024,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ligue Contre le Cancer; Fondation ARC pour la Recherche sur le Cancer; Institut National de la Santé et de la Recherche Médicale; Sunnybrook Research Institute","keywords":"Radioresistance; Prostate cancer; Cancer research; DNA methylation; DNA repair; Downregulation and upregulation; microRNA; DNA damage; Radiosensitivity; Biology; Radiation therapy; Cancer; Medicine; DNA; Gene expression; Gene; Internal medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009677051,0.0001633136,0.0002293492,0.0002248079,0.000166447,0.0003844309,0.0001182789,0.0002566181,0.001510229],"category_scores_gemma":[0.0001759141,0.0001613567,0.0002323195,0.0001465612,0.0002099447,0.0001489492,0.0001538498,0.0005987643,0.0004279385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511743,"about_ca_system_score_gemma":0.0002761105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007473283,"about_ca_topic_score_gemma":0.0007230692,"domain_scores_codex":[0.9998796,0.00001826105,0.000008120791,0.00002598187,0.0000438699,0.00002413658],"domain_scores_gemma":[0.9999024,0.0000163485,0.00003014231,0.000009378177,0.00001286154,0.00002890019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002679978,0.00003896759,0.001253275,0.00005164046,0.00001538177,0.0001380397,0.00002705592,0.0001152533,0.9954312,0.0001324317,0.0001562935,0.00237248],"study_design_scores_gemma":[0.00003489746,0.000605716,0.05183316,0.00001349309,0.00007614728,0.001773046,0.0001084019,0.003913776,0.9327466,0.0002581819,0.008617257,0.00001926859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914166,0.002649331,0.003503246,0.0001656938,0.00004432536,0.00002777672,0.0004329146,0.0002157245,0.001544351],"genre_scores_gemma":[0.9973409,0.0004900752,0.0005807617,0.00005821982,0.000004552398,0.00002153604,0.0002560085,0.00002334816,0.001224731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510229,"threshold_uncertainty_score":0.005052209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006093579254594171,"score_gpt":0.2387769624298157,"score_spread":0.2326833831752216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}