{"id":"W4403461325","doi":"10.21203/rs.3.rs-4359582/v1","title":"Methylation Mesa define functional regulatory elements for targeted gene activation","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"National Heart, Lung, and Blood Institute; Cancer Science Institute of Singapore, National University of Singapore; Ministry of Education, India; Medical Research Council; National Health and Medical Research Council; Canada Research Chairs; National Institutes of Health; Fondazione Cariplo; National Research Foundation Singapore; National Cancer Institute; National Medical Research Council; National Research Foundation; Bristol-Myers Squibb; Associazione Italiana per la Ricerca sul Cancro; U.S. Department of Defense","keywords":"DNA methylation; Epigenetics; Chromatin; CpG site; Biology; Methylation; Histone; Genetics; Epigenome; Regulation of gene expression; Demethylation; DNA demethylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004134367,0.0004161651,0.0003980203,0.0004896905,0.0003526251,0.0007810326,0.0005247554,0.0006114052,0.005187301],"category_scores_gemma":[0.0006027329,0.0006629333,0.0003749648,0.0002264195,0.00059176,0.0006096279,0.000856708,0.00116576,0.002268751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003855222,"about_ca_system_score_gemma":0.0002109603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003151294,"about_ca_topic_score_gemma":0.0007609574,"domain_scores_codex":[0.9996736,0.00004332809,0.00001682805,0.0001197909,0.00007675221,0.00006979704],"domain_scores_gemma":[0.9995916,0.0001431947,0.0000637025,0.00009874391,0.00003388901,0.00006878377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000190728,0.00001394962,0.0004378037,0.00002636701,0.000005590747,0.00006400359,0.00003746146,0.0001995139,0.9902375,0.005211302,0.0001168136,0.003458901],"study_design_scores_gemma":[0.00001690397,0.00005101295,0.004514354,0.000004372715,0.000008707301,0.0001358403,0.00003100029,0.001349069,0.9880364,0.002489432,0.003354236,0.000008548812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9011332,0.00198442,0.07721035,0.0003083257,0.0001394604,0.0001275179,0.00133412,0.001431506,0.01633105],"genre_scores_gemma":[0.9780005,0.0002342369,0.01370135,0.0001153206,0.00002849347,0.00006107726,0.0007975278,0.0002360486,0.006825599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005187301,"threshold_uncertainty_score":0.01735324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06853049254795616,"score_gpt":0.3873276901629198,"score_spread":0.3187971976149636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}