{"id":"W4403461344","doi":"10.1111/epi.18150","title":"Exogenous ketones exert antiseizure effects and modulate the gut microbiome and mycobiome in a clinically relevant murine model of epilepsy","year":2024,"lang":"en","type":"article","venue":"Epilepsia","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Children's Hospital Research Institute","keywords":"Epilepsy; Microbiome; Bacteroides; Feces; Biology; Lactobacillus; Physiology; Medicine; Internal medicine; Microbiology; Bioinformatics; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002528575,0.0007509295,0.0004762046,0.0005898058,0.0001717048,0.0003527785,0.0002301768,0.0004312223,0.001185845],"category_scores_gemma":[0.0001465421,0.0001887037,0.0003282274,0.0001903861,0.0005343383,0.0004479787,0.0002277734,0.0009885159,0.0002840157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000280907,"about_ca_system_score_gemma":0.000303152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003619111,"about_ca_topic_score_gemma":0.000944768,"domain_scores_codex":[0.9997299,0.00004410465,0.00003474535,0.00005028232,0.00007176842,0.00006913978],"domain_scores_gemma":[0.9997223,0.00001757658,0.0001304722,0.00002873798,0.00002155372,0.00007924814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001412403,0.0002980913,0.0006671082,0.00007519352,0.0000154622,0.000101521,0.00002553792,0.0001080334,0.9948044,0.00005281511,0.0000541515,0.002385327],"study_design_scores_gemma":[0.0002353223,0.01302373,0.01780223,0.00004010354,0.0001005976,0.0006685588,0.0001980758,0.001448164,0.9643555,0.0001154528,0.001988643,0.00002367274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962177,0.001069825,0.001368294,0.0001501145,0.00004084555,0.00005660599,0.0004532772,0.0000904675,0.0005529023],"genre_scores_gemma":[0.9941601,0.001279283,0.001972694,0.0001054236,0.00001951559,0.0001124339,0.0004466705,0.00002048323,0.001883386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001185845,"threshold_uncertainty_score":0.003966987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008596967577705884,"score_gpt":0.263283039690426,"score_spread":0.2546860721127201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}