{"id":"W4403471106","doi":"10.1016/j.mtbio.2024.101298","title":"Cuproptosis-based layer-by-layer silk fibroin nanoplatform-loaded PD-L1 siRNA combining photothermal and chemodynamic therapy against metastatic breast cancer","year":2024,"lang":"en","type":"article","venue":"Materials Today Bio","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"","keywords":"Fibroin; Photothermal therapy; Layer (electronics); Cancer research; Materials science; Chemistry; Nanotechnology; SILK; Medicine; Composite material","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002784274,0.0006066461,0.0006319784,0.0002401966,0.0001234525,0.0004736187,0.0002615393,0.0001936721,0.000895242],"category_scores_gemma":[0.00000605904,0.0005154007,0.0001120624,0.0003084988,0.0001006517,0.0004330144,0.00004612724,0.0002096092,0.00008010392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002600684,"about_ca_system_score_gemma":0.0001011284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001491004,"about_ca_topic_score_gemma":0.0000174517,"domain_scores_codex":[0.9978673,0.00003130692,0.0005943067,0.000483509,0.0003252261,0.0006983335],"domain_scores_gemma":[0.9992482,0.00009255478,0.00008667416,0.0003638027,0.00004213339,0.0001666227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002085596,0.00003951081,0.00006064036,0.0005810587,0.0002872161,0.00002555511,0.0002712109,0.0009063741,0.991928,0.00003132904,0.000688454,0.004972082],"study_design_scores_gemma":[0.001617049,0.00008398958,0.0001667772,0.000464408,0.00007522999,0.00002397466,0.00003684836,0.01133111,0.9821453,0.000122689,0.003251949,0.0006806917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898598,0.004593766,0.0005153346,0.0001277296,0.001710433,0.0006436787,0.001546739,0.000811611,0.0001909724],"genre_scores_gemma":[0.9974908,0.0009074498,0.0003222738,0.0002944986,0.0001655501,0.0001922864,0.0001836251,0.0002585426,0.0001850219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01042474,"threshold_uncertainty_score":0.9997298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306627500920465,"score_gpt":0.2356438806183618,"score_spread":0.2225776056091572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}