{"id":"W4403476460","doi":"10.1016/j.jtho.2024.09.812","title":"EP.02G.01 Differentiation and Metabolic Phenotypes of Lung Squamous Cell Carcinoma Organoids are Modified by the Tumor Microenvironments","year":2024,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto","funders":"","keywords":"Organoid; Medicine; Phenotype; Basal cell; Lung; Cancer research; Carcinoma; Pathology; Oncology; Internal medicine; Cell biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002083024,0.0002401615,0.0003440293,0.0005025343,0.0003817695,0.00133858,0.0002959833,0.0007811955,0.06983312],"category_scores_gemma":[0.0002321671,0.0001592979,0.0003445366,0.0003201819,0.000409836,0.0002856421,0.0005623909,0.001145032,0.02480613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004221782,"about_ca_system_score_gemma":0.000519469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00098394,"about_ca_topic_score_gemma":0.0008025412,"domain_scores_codex":[0.9997935,0.00003583801,0.00001011972,0.00004001929,0.00005295101,0.00006768889],"domain_scores_gemma":[0.9998358,0.00002112275,0.00001739646,0.00002355077,0.00002918508,0.00007290544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003555263,0.0006455826,0.006919076,0.0006344828,0.0001179365,0.004367754,0.0002817972,0.0006381021,0.8154757,0.01318378,0.03632958,0.1178509],"study_design_scores_gemma":[0.0006783339,0.002073892,0.1664775,0.0003460983,0.0002257276,0.01033056,0.001128881,0.00290733,0.2946068,0.00579572,0.515345,0.0000841546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6627149,0.01507575,0.007076509,0.01000846,0.003437411,0.0002987866,0.01459524,0.001334414,0.2854586],"genre_scores_gemma":[0.764452,0.003828595,0.002652426,0.001432939,0.0002970412,0.0002473937,0.006761272,0.0003838211,0.2199444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06983312,"threshold_uncertainty_score":0.2336151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035010994945471,"score_gpt":0.3426637841896223,"score_spread":0.3323136742401676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}