{"id":"W4403478612","doi":"10.1002/alz.14299","title":"Frontoparietal network integrity supports cognitive function in pre‐symptomatic frontotemporal dementia: Multimodal analysis of brain function, structure, and perfusion","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Western University; McGill University; University of Toronto; Montreal Neurological Institute and Hospital; Université Laval; Health Sciences Centre; McGill University Health Centre; Sunnybrook Health Science Centre","funders":"NIHR Cambridge Biomedical Research Centre; Medical Research Council; Alzheimer Nederland; Instituto de Salud Carlos III; ZonMw; Brain Research UK; Deutsche Forschungsgemeinschaft; Brain Foundation; University College London; Stichting Dioraphte; University of Cambridge; Weston Brain Institute; Guarantors of Brain; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Cambridge Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Alzheimer's Society; Wellcome Trust; Vetenskapsrådet; Ministero della Salute; Ontario Brain Institute","keywords":"Frontotemporal dementia; Dementia; Neuroscience; Cognition; White matter; Psychology; Medicine; Internal medicine; Radiology; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000360845,0.0003319657,0.0001879732,0.0009149876,0.0002389674,0.0003568194,0.0001816327,0.0002281995,0.001464667],"category_scores_gemma":[0.001033647,0.0001053783,0.0001522148,0.0003556674,0.0002742012,0.0003284349,0.0002513447,0.000162355,0.0001012965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000313915,"about_ca_system_score_gemma":0.0002003811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003547719,"about_ca_topic_score_gemma":0.007913762,"domain_scores_codex":[0.9999279,0.00001849328,0.000006844979,0.00001806615,0.0000133882,0.00001539109],"domain_scores_gemma":[0.9997373,0.0000628149,0.0001108477,0.00002439437,0.00003090382,0.00003370111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008111096,0.0001125157,0.9676239,0.00005733035,0.0002132557,0.000856098,0.0005114594,0.0007053573,0.01395964,0.0001591107,0.0002176555,0.01477258],"study_design_scores_gemma":[0.000003487294,0.00005915385,0.9975092,0.000006241642,0.00004196481,0.0005929871,0.0000890813,0.0007515081,0.0006898899,0.0001935148,0.00005963151,0.000003361056],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994097,0.00008504614,0.0001138741,0.00001261118,6.154635e-7,0.000003528354,0.000103719,0.000002723569,0.0002683403],"genre_scores_gemma":[0.9997802,0.00002357226,0.00008566616,0.00000219529,0.000001213409,0.000002541002,0.00006132165,5.468185e-7,0.00004277289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003547719,"threshold_uncertainty_score":0.00705415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01436477753838725,"score_gpt":0.2958658021851889,"score_spread":0.2815010246468017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}