{"id":"W4403479144","doi":"10.1093/brain/awae325","title":"Amyloid-β predominant Alzheimer’s disease neuropathologic change","year":2024,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University Health Network","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; University of California, San Francisco; Stichting MS Research; Canadian Institutes of Health Research; Pfizer; University of Washington; University of California, Los Angeles; Genentech; National Institutes of Health; H. Lundbeck A/S; Foundation for the National Institutes of Health; University of Southern California; Eisai; National Cancer Institute; Medical Research Council; Servier; Newcastle University; Northern California Institute for Research and Education; University of California, San Diego; Johns Hopkins University; York University; University of Miami; Northwestern University; Biogen; BioClinica; Emory University; U.S. Department of Veterans Affairs; University of Pennsylvania; Vanderbilt University; Massachusetts General Hospital; Novartis Pharmaceuticals Corporation; IXICO; University of Pittsburgh; Office of Research and Development; Alzheimer's Association; Alzheimer's Research Trust; U.S. Department of Defense; Hersenstichting; Eli Lilly and Company; North Bristol NHS Trust; Bristol-Myers Squibb; Wellcome Trust; Universitat de Barcelona; Rush University; Meso Scale Diagnostics","keywords":"Alzheimer's disease; Amyloid (mycology); Medicine; Neuropathology; Disease; Pathology; Neuroscience; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001644988,0.0001838238,0.0001904192,0.0001443061,0.0000809873,0.00005584332,0.00008566202,0.0000444574,0.0005885776],"category_scores_gemma":[0.0001238193,0.0001313806,0.0001701169,0.0002441539,0.0001007942,0.0001183801,0.00008822472,0.0001584641,0.001846468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003730112,"about_ca_system_score_gemma":0.0001941479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002121434,"about_ca_topic_score_gemma":0.000001689432,"domain_scores_codex":[0.9985251,0.00009088287,0.0001444244,0.0004310441,0.0003370083,0.0004715579],"domain_scores_gemma":[0.9988071,0.0001010966,0.00001651047,0.0003585513,0.00003445064,0.0006823344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00463205,0.004555217,0.08903152,0.001437839,0.01482082,0.2269575,0.001379041,0.000002298239,0.00170695,0.007943639,0.1922795,0.4552536],"study_design_scores_gemma":[0.00526793,0.002316411,0.8434994,0.001186327,0.005512725,0.0008174033,0.000133544,0.004830493,0.0009869514,0.002750313,0.1317586,0.0009399012],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5862104,0.3596684,0.00006397964,0.0417032,0.0007419245,0.00355276,0.0004970082,0.001145696,0.006416682],"genre_scores_gemma":[0.9966862,0.0003744956,0.00007618252,0.00143092,0.000426794,0.0002991239,0.0001322835,0.00004497926,0.0005290575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7544679,"threshold_uncertainty_score":0.9989307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08079977414007414,"score_gpt":0.3540275354758803,"score_spread":0.2732277613358062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}