{"id":"W4403479144","doi":"10.1093/brain/awae325","title":"Amyloid-β predominant Alzheimer’s disease neuropathologic change","year":2024,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University Health Network","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; University of California, San Francisco; Stichting MS Research; Canadian Institutes of Health Research; Pfizer; University of Washington; University of California, Los Angeles; Genentech; National Institutes of Health; H. Lundbeck A/S; Foundation for the National Institutes of Health; University of Southern California; Eisai; National Cancer Institute; Medical Research Council; Servier; Newcastle University; Northern California Institute for Research and Education; University of California, San Diego; Johns Hopkins University; York University; University of Miami; Northwestern University; Biogen; BioClinica; Emory University; U.S. Department of Veterans Affairs; University of Pennsylvania; Vanderbilt University; Massachusetts General Hospital; Novartis Pharmaceuticals Corporation; IXICO; University of Pittsburgh; Office of Research and Development; Alzheimer's Association; Alzheimer's Research Trust; U.S. Department of Defense; Hersenstichting; Eli Lilly and Company; North Bristol NHS Trust; Bristol-Myers Squibb; Wellcome Trust; Universitat de Barcelona; Rush University; Meso Scale Diagnostics","keywords":"Alzheimer's disease; Amyloid (mycology); Medicine; Neuropathology; Disease; Pathology; Neuroscience; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000516975,0.0002414247,0.0003805297,0.0007151773,0.0004056635,0.0004864807,0.0002144215,0.0001440989,0.001614003],"category_scores_gemma":[0.0008172853,0.0001120826,0.0001734588,0.0006300852,0.0002079584,0.0002455314,0.0002844773,0.0001787818,0.0002484434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000161721,"about_ca_system_score_gemma":0.0001400511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003203286,"about_ca_topic_score_gemma":0.004609443,"domain_scores_codex":[0.9997401,0.0000501453,0.00004388885,0.00007345639,0.00004898312,0.00004343706],"domain_scores_gemma":[0.9996527,0.00004495554,0.0001229221,0.00005147473,0.00007039138,0.00005744695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001061987,0.00005052948,0.9873815,0.00003979736,0.0001010781,0.0003687596,0.0002217512,0.00003676662,0.005620633,0.0001215689,0.000184697,0.004811057],"study_design_scores_gemma":[0.00001345493,0.0001314966,0.9973578,0.000006936131,0.00003353801,0.001202562,0.000175176,0.00005882053,0.0004632072,0.00014519,0.000408784,0.000003058779],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984435,0.0001563759,0.00009741803,0.000005939082,0.000002994163,0.00002197552,0.0003752638,0.000002901564,0.0008936193],"genre_scores_gemma":[0.9987621,0.00008082445,0.0001596232,0.00001301319,0.00000425555,0.00001899911,0.0005847312,0.000001928683,0.0003744675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003203286,"threshold_uncertainty_score":0.006369233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08079977414007414,"score_gpt":0.3540275354758803,"score_spread":0.2732277613358062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}