{"id":"W4403485115","doi":"10.1001/jamaoncol.2024.4381","title":"Lenvatinib Plus Ifosfamide and Etoposide in Children and Young Adults With Relapsed Osteosarcoma","year":2024,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute","keywords":"Medicine; Ifosfamide; Lenvatinib; Internal medicine; Etoposide; Clinical endpoint; Oncology; Response Evaluation Criteria in Solid Tumors; Clinical trial; Surgery; Phases of clinical research; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001609318,0.0001608456,0.0003654413,0.0001582772,0.00003557251,0.00003299067,0.00003386208,0.0001686232,0.00002320589],"category_scores_gemma":[0.00005529317,0.0001139955,0.0000291517,0.0001603508,0.0001151089,0.00008020079,0.00005355488,0.0002921676,0.00001567663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002129581,"about_ca_system_score_gemma":0.0001727678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008480368,"about_ca_topic_score_gemma":0.001267519,"domain_scores_codex":[0.998959,0.00006305974,0.0002117766,0.0003912892,0.0001138252,0.0002610319],"domain_scores_gemma":[0.9994171,0.0002586379,0.00003431709,0.0001544616,0.00002374474,0.0001117078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006876632,0.000210759,0.8589875,0.00006019601,0.0001457964,0.001771699,0.00116376,5.564082e-7,0.00007116958,0.0009052375,0.001117619,0.1348781],"study_design_scores_gemma":[0.009252315,0.001836011,0.981195,0.0004165527,0.0001524003,0.003938786,0.000299981,0.0001821797,0.0001713224,0.000196418,0.002238724,0.0001202834],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786214,0.01018222,0.000003381361,0.007541623,0.00008654752,0.0006225121,0.0000120745,0.00006223513,0.00286804],"genre_scores_gemma":[0.996611,0.001326854,0.0008068571,0.0007523162,0.0001060607,0.0001153585,0.00004197862,0.00002526488,0.00021431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1347578,"threshold_uncertainty_score":0.4648601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008763653281383671,"score_gpt":0.2691236233659202,"score_spread":0.2603599700845365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}