{"id":"W4403489208","doi":"10.1242/dev.202829","title":"Planar cell polarity zebrafish models of congenital scoliosis reveal underlying defects in notochord morphogenesis","year":2024,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital; Université de Montréal; Polytechnique Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Fonds de Recherche du Québec - Santé; Institut TransMedTech; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canada Foundation for Innovation; Shriners Hospitals for Children","keywords":"Notochord; Convergent extension; Zebrafish; Biology; Cell biology; Morphogenesis; Anatomy; Extracellular matrix; Axial skeleton; Embryogenesis; Genetics; Embryo; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001290135,0.0007051995,0.0003313569,0.0009035802,0.0003607412,0.0002703046,0.0003503118,0.0006750334,0.003095587],"category_scores_gemma":[0.0001426744,0.0002720488,0.0003984174,0.0002230467,0.0007359732,0.0003282928,0.0004010885,0.0009637622,0.0005651058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000680711,"about_ca_system_score_gemma":0.0006687457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004511805,"about_ca_topic_score_gemma":0.01012189,"domain_scores_codex":[0.9997279,0.00002327756,0.00002180956,0.00006470369,0.000111133,0.00005106869],"domain_scores_gemma":[0.9998159,0.00002262144,0.00007023628,0.0000162715,0.0000226212,0.0000524051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004268573,0.00000925424,0.0001963411,0.00003692131,0.000005616316,0.0001762476,0.00001812366,0.00007595409,0.998179,0.0004505624,0.00007072884,0.0007386259],"study_design_scores_gemma":[0.00005590039,0.0004009364,0.01239009,0.0000299541,0.0000586045,0.001453748,0.0001028748,0.001794111,0.9775876,0.0003733592,0.005729759,0.00002294241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971674,0.002326572,0.01618603,0.0006857628,0.0001257391,0.0001207412,0.002346997,0.0005457162,0.005988381],"genre_scores_gemma":[0.9778151,0.001695551,0.008639047,0.0001285186,0.00000967506,0.00009924633,0.001035851,0.00008573145,0.01049145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004511805,"threshold_uncertainty_score":0.01035583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732580963222439,"score_gpt":0.2908450703173038,"score_spread":0.2535192606850795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}