{"id":"W4403489208","doi":"10.1242/dev.202829","title":"Planar cell polarity zebrafish models of congenital scoliosis reveal underlying defects in notochord morphogenesis","year":2024,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital; Université de Montréal; Polytechnique Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Fonds de Recherche du Québec - Santé; Institut TransMedTech; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canada Foundation for Innovation; Shriners Hospitals for Children","keywords":"Notochord; Convergent extension; Zebrafish; Biology; Cell biology; Morphogenesis; Anatomy; Extracellular matrix; Axial skeleton; Embryogenesis; Genetics; Embryo; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003163989,0.0001826181,0.0001949494,0.000219407,0.00005530774,0.00004519981,0.0001923066,0.0001640158,0.00001432479],"category_scores_gemma":[0.00002850159,0.0001920046,0.00008844868,0.0003250953,0.00005001224,0.00001416978,0.0001715886,0.00015126,0.00002823898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009273386,"about_ca_system_score_gemma":0.0005299493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001329141,"about_ca_topic_score_gemma":0.0005510871,"domain_scores_codex":[0.998519,0.00007149574,0.0003267242,0.0004435536,0.0002557604,0.0003834709],"domain_scores_gemma":[0.9995188,0.0000235745,0.00002744959,0.0002381588,0.00007585919,0.0001161717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008824551,0.00009193687,0.004764234,0.0003222342,0.00008024724,0.00005932765,0.0002588822,0.0000465622,0.990358,0.00007760873,0.000187964,0.003664792],"study_design_scores_gemma":[0.0005029074,0.0001823475,0.02135143,0.0001353969,0.00001818716,0.00003705121,0.0001190528,0.0003422365,0.9743062,0.0002893668,0.002333072,0.0003827772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940329,0.003185346,0.0006480838,0.00003483394,0.000105137,0.0004543756,0.00003028074,0.00001940879,0.001489585],"genre_scores_gemma":[0.9974366,0.0000510759,0.001698039,0.0000423634,0.00003134661,0.00008221337,0.00006819383,0.00003351554,0.0005566332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0165872,"threshold_uncertainty_score":0.7829719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732580963222439,"score_gpt":0.2908450703173038,"score_spread":0.2535192606850795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}