{"id":"W4403501372","doi":"10.1016/j.jbc.2024.107896","title":"Discovery, characterization, and structure of a cofactor-independent histidine racemase from the oral pathogen Fusobacterium nucleatum","year":2024,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Basic Energy Sciences; National Institute of Dental and Craniofacial Research; National Institute of General Medical Sciences; Biological and Environmental Research; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Office of Science; National Institutes of Health; University of Alberta; U.S. Department of Energy","keywords":"Fusobacterium nucleatum; Cofactor; Pathogen; Histidine; Microbiology; Biochemistry; Fusobacterium; Chemistry; Periodontal pathogen; Biology; Bacteria; Porphyromonas gingivalis; Enzyme; Bacteroides","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000190267,0.000390225,0.0003824149,0.000209484,0.0001872837,0.0004933226,0.0003554178,0.0005859439,0.0003382555],"category_scores_gemma":[0.0004710774,0.000147797,0.0003992597,0.0003334282,0.0001636019,0.0003516154,0.0002627203,0.0006109209,0.0003889257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004396778,"about_ca_system_score_gemma":0.0003198418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00203681,"about_ca_topic_score_gemma":0.001204428,"domain_scores_codex":[0.9998868,0.00001337059,0.0000125268,0.00002918807,0.00003493895,0.00002323967],"domain_scores_gemma":[0.9997602,0.00003824036,0.0000677909,0.0000245112,0.00005339004,0.00005585865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001473824,0.00004823531,0.001966005,0.00007788344,0.00001362234,0.0005668025,0.0001183065,0.000338424,0.9921475,0.0001185174,0.0001174148,0.004339957],"study_design_scores_gemma":[0.00006358606,0.0008065357,0.03905309,0.00003435239,0.0001098847,0.002906654,0.0003909614,0.006494949,0.929908,0.0002521304,0.0199203,0.00005955611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920223,0.002185385,0.004128449,0.000207828,0.00003618114,0.00003802481,0.0006212974,0.00003813194,0.0007224855],"genre_scores_gemma":[0.982228,0.001559682,0.01007874,0.0001304579,0.00002852433,0.00001828983,0.004365894,0.00003379901,0.001556614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203681,"threshold_uncertainty_score":0.004049897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186354709241316,"score_gpt":0.2205181839764422,"score_spread":0.2086546368840291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}