{"id":"W4403512247","doi":"10.3389/fimmu.2024.1452788","title":"Circulating IL-17F, but not IL-17A, is elevated in severe COVID-19 and leads to an ERK1/2 and p38 MAPK-dependent increase in ICAM-1 cell surface expression and neutrophil adhesion on endothelial cells","year":2024,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mila - Quebec Artificial Intelligence Institute; Children’s Health Research Institute; McGill University Health Centre; Lawson Health Research Institute; Western University; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Lung Association; Fonds de Recherche du Québec - Santé; Public Health Agency; Public Health Agency of Canada","keywords":"p38 mitogen-activated protein kinases; Interleukin 17; ICAM-1; Coronavirus disease 2019 (COVID-19); MAPK/ERK pathway; Expression (computer science); Cell biology; Immunology; Medicine; Inflammation; Biology; Signal transduction; Internal medicine; Computer science; Cell adhesion molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001948642,0.0004175534,0.000381412,0.0003544406,0.0003433425,0.0003517476,0.00017989,0.0003094633,0.002519996],"category_scores_gemma":[0.0003320324,0.0002341003,0.0002538772,0.0003039591,0.0003129033,0.0001024383,0.0001912191,0.000527875,0.000210377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007282645,"about_ca_system_score_gemma":0.0004480537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01153405,"about_ca_topic_score_gemma":0.01975279,"domain_scores_codex":[0.9998502,0.00002113115,0.000009770587,0.0000369857,0.00003926425,0.00004268285],"domain_scores_gemma":[0.9996191,0.00002797127,0.0001738651,0.00002118082,0.00003917051,0.0001186055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00335183,0.0002028781,0.8197129,0.00009387823,0.0001537423,0.001410087,0.0001238108,0.0001134228,0.1702981,0.00005306574,0.0004633971,0.004022882],"study_design_scores_gemma":[0.00003310246,0.0003014507,0.9949089,0.000007485449,0.00002499961,0.0009494028,0.00008453059,0.0001299012,0.003198381,0.00001713096,0.0003406378,0.000004084201],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998895,0.0002105147,0.0001331177,0.00003202078,0.000005735506,0.00001652962,0.0004765233,0.000004789243,0.0002257972],"genre_scores_gemma":[0.9985436,0.0001335622,0.000180021,0.00003437227,0.00000904128,0.00002106265,0.0007630469,0.000003199001,0.0003120167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01153405,"threshold_uncertainty_score":0.02293378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01311478933841042,"score_gpt":0.2356485607071494,"score_spread":0.222533771368739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}